摘要
目的探讨宫颈癌组织及癌旁组织NLRC5(NOD-like receptor family caspase recruitment domain family-containing 5)的表达情况与宫颈癌患者预后的相关性。方法选择2013年1月—2016年6月在安徽医科大学第二附属医院进行诊治的宫颈癌患者,共60例,收集宫颈癌手术的癌组织和癌旁组织,采用免疫组化的方法检测宫颈癌组织及癌旁组织中NLRC5的表达并分析其与宫颈癌患者预后的相关性。结果在宫颈癌组织中,NLRC5的阳性表达低于癌旁组织[15(25.00)%vs.50(83.33%),P<0.05]。对宫颈癌组织内NLRC5表达与患者临床病理特征进行分析,发现NLRC5的阴性表达与宫颈癌的浸润深度和肿瘤大小相关(χ^(2)=11.769、5.926,均P<0.05),NLRC5的表达与年龄、病理类型、有无淋巴结转移等没有相关性(均P>0.05)。绘制宫颈癌的生存预后Kaplan-Meier曲线,发现NLRC5阴性表达患者生存期较阳性表达的患者短(P<0.05)。对宫颈癌预后的相关因素进行单因素或Cox多因素分析,发现NLRC5阴性表达、淋巴结转移、浸润深度是宫颈癌预后的独立影响因素(均P<0.05)。结论与癌旁组织比较,在宫颈癌组织中NLRC5呈现低表达,同时,NLRC5阴性表达是影响宫颈癌患者预后的独立危险因素,这一发现有可能作为宫颈癌诊治的新靶点。
Objective To investigate the correlation between the expression of NLRC5(NOD-like receptor family caspase recruitment domain family-containing 5)in cervical cancer tissue and paracancerous tissue and the prognosis of cervical cancer patients.Methods A total of 60 patients with cervical cancer who were diagnosed and treated in the Second Affiliated Hospital of Anhui Medical University from January 2013 to June 2016 were selected.The cancer tissues and paracancerous tissues of cervical cancer surgery were collected and detected by immunohistochemistry.The expression of NLRC5 in cervical cancer tissues and paracancerous tissues was analyzed,and the correlation between the expression of NLRC5 and the prognosis of cervical cancer patients was analyzed.Results The positive expression of NLRC5 in cervical cancer tissues was lower than that in paracancerous tissues[15(25.00)%vs.50(83.33%),P<0.05].The expression of NLRC5 in cervical cancer tissue and the clinicopathological characteristics of patients were analyzed,and it was found that the negative expression of NLRC5 was correlated with the depth of invasion and tumor size of cervical cancer(χ^(2)=11.769,5.926,all P<0.05).The expression of NLRC5 was not correlated with age,pathological type,lymph node metastasis(all P>0.05).The Kaplan-Meier curve of survival and prognosis of cervical cancer was drawn.It was found that the survival time of patients with negative NLRC5 expression were shorter than those with positive expression(P<0.05).Univariate or Cox multivariate analysis was performed on the prognostic factors of cervical cancer,and it was found that the negative expression of NLRC5,lymphatic metastasis and depth of invasion were independent risk factors for the prognosis of cervical cancer(all P<0.05).Conclusion Compared with paracancerous tissues,NLRC5 shows a low expression pattern in cervical cancer tissues.Meanwhile,the negative expression of NLRC5 is an independent risk factor affecting the prognosis of cervical cancer patients.This finding may be used for the
作者
何闰华
詹磊
宋恩学
卫兵
凌琳
HE Run-hua;ZHAN Lei;SONG En-xue;WEI Bing;LING Lin(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230032,China)
出处
《中华全科医学》
2022年第10期1700-1703,共4页
Chinese Journal of General Practice
基金
国家自然科学基金青年科学基金项目(81802586)
安徽医科大学校科研基金项目(2019xkj040)。
关键词
NLRC5
宫颈癌
生存期
NOD-like receptor family caspase recruitment domain family-containing 5
Cervical cancer
Survival period
