摘要
目的研究血清钙、镁与冠状动脉痉挛综合征的相关性。方法选取2020年1月至2022年1月江西省人民医院收治的因心绞痛确诊为冠状动脉痉挛的15例患者作为冠状动脉痉挛组,另外纳入同期冠脉造影证实冠脉无显著狭窄的15例患者为正常组。统计并比较两组的基础资料,包括性别、年龄、体重指数(BMI)、居住地、文化水平、高血压、吸烟饮酒史、糖尿病、血清钙、镁水平,选择单因素分析中有统计学意义的变量行多因素分析,明确冠状动脉痉挛综合征的危险因素。通过Spearman秩相关系数分析血清钙、镁与冠状动脉痉挛综合征疾病发生的相关性。结果单因素分析结果显示,两组的性别、BMI、居住地、文化水平、钙水平比较,差异无统计学意义(P>0.05);冠状动脉痉挛组的年龄≥60岁、高血压、吸烟饮酒史、糖尿病患者比例高于正常组,镁水平低于正常组,差异有统计学意义(P<0.05)。绘制受试者工作特征(ROC)曲线,结果显示血清镁水平对冠状动脉痉挛综合征疾病发生具有一定的预测价值,曲线下面积为0.769,标准误为0.054,95%CI为0.663~0.875,最佳截断值为0.765 mmol/L,敏感度为0.807,特异度为0.751。多因素logistic回归分析结果显示,年龄≥60岁(β=0.341,OR=1.407,95%CI=1.017~1.947)、高血压(β=0.441,OR=1.554,95%CI=1.242~1.944)、吸烟饮酒史(β=0.358,OR=1.431,95%CI=1.357~1.509)、糖尿病(β=0.514,OR=1.672,95%CI=1.308~2.137)、镁<0.765 mmol/L(β=0.501,OR=1.650,95%CI=1.246~2.185)是冠状动脉痉挛综合征发病的危险因素(P<0.05)。Spearman相关性分析结果显示,钙水平与冠状动脉痉挛综合征疾病发生无相关性(P>0.05),镁水平与冠状动脉痉挛综合征疾病发生呈负相关(r=-0.307,P<0.05)。结论当镁<0.765 mmol/L时,心绞痛患者发生冠状动脉痉挛综合征的可能性较高。
Objective To study the correlation between serum calcium,magnesium and coronary artery spasm syndrome.Methods A total of 15 patients diagnosed with coronary artery spasm due to angina pectoris admitted to Jiangxi Provincial People′s Hospital from January 2020 to January 2022 were selected as the coronary artery spasm group,and another 15 patients without significant coronary artery stenosis confirmed by coronary angiography during the same period were included as the normal group.The basis of statistics and compare the two sets of data,including gender,age,body mass index(BMI),place of residence,cultural level,hypertension,history of smoking and drinking,diabetes,serum calcium and magnesium levels,choose the single factor analysis was statistically significant variables in the line of multi-factor analysis,to determine the risk factors for coronary artery spasm syndrome.Spearman rank correlation coefficient was used to analyze the correlation between serum calcium,magnesium and the occurrence of coronary artery spasm syndrome.Results The results of univariate analysis showed that there were no significant differences in gender,BMI,residence,education level and calcium level between the two groups(P>0.05).The proportion of patients with age≥60 years old,hypertension,history of smoking and drinking,diabetes mellitus in the coronary artery spasm group were higher than those in the normal group,and the magnesium level was lower than that in the normal group,the differences were statistically significant(P<0.05).The receiver operating characteristic(ROC)curve was drawn,and the results showed that serum magnesium level had a certain predictive value for the occurrence of coronary artery spasm syndrome.The area under the curve was 0.769,the standard error was 0.054,the 95%CI was 0.633-0.875,the best cut-off value was 0.765 mmol/L,and the sensitivity was 0.807,the specificity was 0.751.Multivariate logistic regression analysis showed that age≥60 years old(β=0.341,OR=1.407,95%CI=1.017-1.947),hypertension(β=0.441,O
作者
谢耀武
叶锦华
吴黎明
杜莎
XIE Yaowu;YE Jinhua;WU Liming;DU Sha(Department of Cardiology,Jiangxi Provincial People′s Hospital,the First Affiliated Hospital of Nanchang Medical College,Jiangxi Province,Nanchang 330000,China;Department of Cardiology,Zhangshu People′s Hospital,Jiangxi Province,Zhangshu 331200,China;Department of Cardiology,Anfu County People′s Hospital,Jiangxi Province,Anfu 343299,China)
出处
《中国当代医药》
CAS
2022年第30期21-25,共5页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202210168)。
关键词
钙
镁
冠状动脉痉挛综合征
心绞痛
Calcium
Magnesium
Coronary artery spasm syndrome
Angina pectoris
