摘要
目的 探讨血栓通联合氯吡格雷及阿司匹林双重抗血小板治疗短暂性脑缺血发作(transient ischemic attack,TIA)的效果以及对缺血性脑卒中的预防作用。方法 选择2019年1月至2021年3月芜湖市第一人民医院神经内科收治的120例TIA患者,随机分为干预组及对照组。对照组采用氯吡格雷(一日75 mg)+阿司匹林(一日100 mg)双重抗血小板治疗,干预组在对照组基础上加用血栓通,疗程2周。观察两组ABCD3-Ⅰ评分、血凝指标、血脂指标、血流变指标变化以及缺血性脑卒中发生情况。结果 120例患者最终109例完成治疗,对照组55例,干预组54例。两组治疗后ABCD3-Ⅰ评分、总胆固醇(total cholesterol,TC)、三酰甘油(triglycerides,TG)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、纤维蛋白原(fibrinogen,FIB)、血浆黏度及红细胞聚集指数均较治疗前降低(P<0.05),高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、凝血酶时间(thrombin time,TT)及活化部分凝血活酶时间(activated partial thromboplastin time,APTT)较治疗前增高(P<0.05)。干预组治疗后ABCD3-Ⅰ评分、TG、TC、LDL-C、FIB、血浆黏度及红细胞聚集指数低于对照组(P<0.05),HDL-C、TT及APTT高于对照组(P<0.05)。干预组发病后1个月及3个月缺血性脑卒中发生率低于对照组(14.55% vs 1.85%,10.91% vs 0.00%,P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论 血栓通联合双重抗血小板治疗可更有效地改善血脂、血凝和血流变指标,并降低TIA脑卒中发生风险和发病率。
Objective To investigate the efficacy of Xueshuantong combined with clopidogrel and aspirin in the treatment of transient ischemic attack(TIA) and the prevention of ischemic stroke.Methods A total of 120 TIA patients admitted to the Department of Neurology of Wuhu NO.1 People’s Hospital from October 2019 to March 2021 were selected,and randomly divided into intervention group and control group.The control group was treated with clopidogrel(75 mg each day) and aspirin(100 mg each day),and the intervention group was additionally treated with Xueshuantong on the basis of the control group,the course of the treatment was 2 weeks.ABCD3-Ⅰ score,blood coagulation index,blood lipid index,hemorheology index and the incidence of ischemic stroke were observed in both groups.Results A total of 109 patients completed treatment,including 55 in the control group and 54 in the intervention group.After treatment,the ABCD3-Ⅰ score,total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C),fibrinogen(FIB),plasma viscosity and erythrocyte aggregation index in the two groups were decreased compared with those before treatment(P0.05).Conclusion Xueshuantong combined with dual antiplatelet therapy can effectively improve blood lipid,blood coagulation and hemorheology,and reduce the risk of stroke.
作者
左健
陈后勤
徐钧
邵凌云
汪文兵
吴有丽
丁志远
ZUO Jian;CHEN Houqin;XU Jun;SHAO Lingyun;WANG Wenbing;WU Youli;DING Zhiyuan(Department of Neurology,Wuhu NO.1 People's Hospital,Wuhu 241060,Anhui Province,China)
出处
《世界临床药物》
CAS
2022年第8期1051-1057,共7页
World Clinical Drug
基金
皖南医学院教学医院科研专项资助项目(JXYY202023)。
