摘要
目的 观察参斛莪术颗粒联合穴位贴敷对气阴两虚、胃络瘀阻型老年慢性胃炎患者的影响。方法 选取收治的100例行气阴两虚、胃络瘀阻型老年慢性胃炎患者作为研究对象,随机分为对照组和治疗组,每组50例。对照组给予奥美拉唑肠溶胶囊治疗,治疗组给予参斛莪术颗粒联合穴位贴敷治疗。对2组患者治疗后的疗效进行评价;比较治疗前后2组中医症候积分、胃黏膜、血红蛋白(Hb)、血小板(PLT)及相关炎症指标变化、治疗期间不良反应发生率及治疗后及停药3个月幽门螺旋杆菌(Hp)阴性率变化。结果 治疗4周后,治疗组治疗有效率高于对照组(P<0.05);治疗后2组中医症候积分均降低,且治疗组低于对照组(P<0.05);治疗后2组胃黏膜病理指标评分[萎缩程度、肠上皮化生(IM)和异型增生(Dys)]降低,且治疗组低于对照组(P<0.05);治疗后2组Hb、PLT数量增加,且治疗组高于对照组(P<0.05),血清中炎症因子[C-反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]水平均降低,且治疗组低于对照组(P<0.05);治疗后2组Hp阴性率升高,且治疗组高于对照组(P<0.05);治疗后3个月,治疗组Hp阴性率均高于对照组(P<0.05);治疗期间,2组不良反应发生率比较差异无统计学意义。结论 参斛莪术颗粒联合穴位贴敷治疗气阴两虚、胃络瘀阻型老年慢性胃炎患者效果明显,能改善胃黏膜状态,防止贫血发生,调节体内炎症因子水平,提升Hp转阴率,安全性较高。
Objective To observe the effects of Shenhu Ezhu Granules combined with acupoint application in elderly patients with chronic gastritis of Qi-yin deficiency and stomach-collaterals stasis types.Methods A total of 100 elderly patients with chronic gastritis of Qi-yin deficiency and stomach-collaterals stasis types were enrolled as the research objects. They were randomly divided into control group and treatment group, 50 cases in each group. The control group were treated with Omeprazole Enteric-coated Capsules, while the treatment group were treated with Shenhu Ezhu Granules and acupoint application. The curative effect of the 2 groups after treatment was evaluated. The changes in scores of traditional Chinese medicine(TCM) syndrome, gastric mucosa, hemoglobin(Hb), platelet(PLT) and related inflammatory indexes before and after treatment, the incidence of adverse reactions during treatment, and the changes in negative rate of Helicobacter pylori(Hp) after treatment and at 3 months after withdrawal were compared between the 2 groups.Results After 4 weeks of treatment, the response rate of treatment in treatment group was higher than that in control group(P<0.05). After treatment, the scores of TCM syndromes in both groups were decreased, which were lower in treatment group than in control group(P<0.05). After treatment, the scores of gastric mucosal pathological indexes [atrophy degree, intestinal metaplasia(IM), dysplasia(Dys)] in both groups were decreased, which were lower in treatment group than in control group(P<0.05). After treatment, the Hb and PLT count in both groups were increased, which were higher in treatment group than in control group(P<0.05), while the levels of serum inflammatory factors [C-reactive protein(CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)] were decreased, which were lower in treatment group than in control group(P<0.05). During treatment, there was no difference in the incidence of adverse reactions between the 2 groups(P>0.05). After treatment, the negative rate of Hp
作者
赵博雅
刘影
田翠丽
史颖
ZHAO Boya;LIU Ying;TIAN Cuili;SHI Ying(Department of Integrated Traditional Chinese and Western Medicine,Hebei 8th People s Hospital,Shijiazhuang 050021,China;Department of Rehabilitation Medicine,Hebei 8th People s Hospital,Shijiazhuang 050021,China)
出处
《西北药学杂志》
CAS
2022年第6期133-137,共5页
Northwest Pharmaceutical Journal
基金
河北省中医药管理局科研计划项目(编号:2020224)。
关键词
参斛莪术颗粒
穴位贴敷
气阴两虚、胃络瘀阻型
胃黏膜
幽门螺旋杆菌(Hp)
Shenhu Ezhu Granules
acupoint application
Qi-yin deficiency and stomach-collaterals stasis
gastric mucosa
Helicobacter pylori(Hp)
