摘要
人类免疫缺陷病毒(HIV)感染者存在不同程度的免疫缺陷,可能导致新型冠状病毒疫苗接种的有效性低于正常人群。HIV感染者应是新型冠状病毒疫苗加强针的优先群体,然而目前国内外尚未检索到HIV感染者接种新型冠状病毒灭活疫苗后使用腺病毒载体疫苗序贯加强免疫的报道。故本文报告1例HIV感染者,通过抗逆转录病毒治疗(ART)后,HIV得到良好抑制,CD4^(+)T细胞计数正常,接种两剂新型冠状病毒灭活疫苗(国药集团中国生物北京生物制品研究所有限责任公司)后使用腺病毒载体疫苗(康希诺生物股份公司)序贯加强免疫,安全且具有高度免疫原性,为指导该人群新型冠状病毒疫苗接种提供参考依据。
People infected with human immunodeficiency virus(HIV) have different degrees of immune deficiency, which may lead to the lower vaccination effectiveness of SARS-CoV-2 vaccines than the normal population. HIV-infected person should be the priority group for booster shots of SARS-CoV-2 vaccines. However, at present, there are no reports of HIV-infected people receiving adenovirus vector vaccines for sequential booster immunization at home and abroad after receiving SARS-CoV-2 inactivated vaccines. Therefore, this paper reports a case of HIV-infected person whose HIV was well suppressed and CD4^(+)T cell count was normal after receiving antiretroviral therapy(ART). After receiving two doses of SARS-CoV-2 inactivated vaccines(Beijing Biological Research Institute of Biological Products, Sinopharm China Co., Ltd.), sequential booster immunization was performed through vaccinating adenovirus vector vaccine(CanSino Biologics Inc., Ltd.), which was safe and highly immunogenic, and can guide the population to vaccinate against SARS-CoV-2.
作者
曾广
奉水东
王晓辉
汤洁
徐六妹
杨峥嵘
ZENG Guang;FENG Shui-dong;WANG Xiao-hui;TANG Jie;XU Liu-mei;YANG Zheng-rong(School of Public Health,University of South China,Hengyang 421000,China;Shenzhen Center for Disease Control and Prevention,Shenzhen 518000,China;The Third People’s Hospital of Shenzhen,Shenzhen 518000,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2022年第10期1015-1018,共4页
Chinese Journal of Infection Control
基金
广东省基础与应用基础研究基金(2019B1515120003)
深圳市科技创新委员会基金(JCYJ20180508152244835)
深圳市医疗卫生三名工程基金(SZSM201811071)。
关键词
人类免疫缺陷病毒
HIV感染者
新型冠状病毒灭活疫苗
腺病毒载体疫苗
序贯加强免疫
抗体反应
不良反应
human immunodeficiency virus
HIV-infected person
inactivated SARS-CoV-2 vaccine
adenovirus vector vaccine
sequential booster immunization
antibody response
adverse reaction
