摘要
近年来,关于幽门螺杆菌(Helicobacter pylori,HP)感染与炎症性肠病(inflammatory bowel disease,IBD)的关系结论不一,多数临床前及回顾性研究结果显示,HP与IBD之间存在负相关,HP感染可能对IBD病情的发展起到保护作用。研究认为这种负相关性与柳氮磺胺吡啶及抗生素用药史、HP的免疫调节特性及环境因素等相关,但IBD发病率的增加与HP根除是否存在直接的因果关系仍不确定。尽管HP感染者应给予根除治疗,但对IBD患者或IBD易感基因携带者,常规根除HP需谨慎。本文就HP感染与IBD的关系、机制及HP根除后IBD的发展作一综述,以期对两者的关系有更全面的认识。
In recent years,there are different conclusions about the relationship between Helicobacter pylori(HP)infection and inflammatory bowel disease(IBD),but most preclinical and retrospective studies report that there is a negative association between HP and IBD.HP infection may reduce the risk of developing IBD.It is considered that this negative association is related to the history of the use of sulfasalazine and antibiotics,the immunomodulatory characteristics of HP and environmental factors.However,whether there is a direct causal relationship between the increased incidence of IBD and HP eradication is still uncertain.Although HP infection should be treated with eradication therapy,routine eradication of HP should be undertaken with caution for IBD patients or IBD susceptible gene carriers.The association between HP infection and IBD as well as the mechanism,and the development of IBD after eradication of HP will be discussed in this paper.
作者
朱明明
冉志华
Ming-Ming ZHU;Zhi-Hua RAN(Department of Gastroenterology,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China;Shanghai Institute of Digestive Diseases,Shanghai 200127,China;Shanghai Inflammatory Bowel Disease Research Center,Shanghai 200127,China;Department of Gastroenterology,Zhoupu Hospital,Shanghai University of Medicine&Health Sciences,Shanghai 201300,China)
出处
《医学新知》
CAS
2022年第5期370-375,共6页
New Medicine
基金
上海市浦江人才计划项目(21PJD038)。
关键词
炎症性肠病
克罗恩病
溃疡性结肠炎
幽门螺杆菌
免疫相关
Inflammatory bowel disease
Crohn's disease
Ulcerative colitis
Helicobacter pylori
Immune-related
