摘要
目的探讨妊娠期糖尿病(GDM)患者产后1年心脏代谢指数(CMI)与糖代谢异常的关系。方法选择在本院产科就诊并生产的102例GDM患者为研究对象,产后随访1年。根据75 g葡萄糖耐量试验(OGTT)结果分为糖代谢异常组和糖代谢正常组,比较两组的各项临床指标。进一步按CMI水平,将GDM患者按三分位数法分为Q1组、Q2组、Q3组,比较三组的各项临床指标及糖代谢异常患病率,采用Pearson相关性分析,分析CMI与临床指标的相关性,并采用Logistic多因素回归分析GDM患者产后糖代谢异常的影响因素。结果与糖代谢正常组比较,糖代谢异常组产后1年的腰围、收缩压、舒张压、内脏脂肪面积、甘油三酯、糖化血红蛋白、空腹血糖及胰岛素水平、2 h血糖及胰岛素水平、稳态模式胰岛素抵抗指数(H0MA-IR)、CMI、体质量指数(BMI)等水平均较高,差异有统计学意义(P<0.05);两组的年龄、皮下脂肪面积、胆固醇、高密度脂蛋白、低密度脂蛋白水平比较,差异无统计学意义(P>0.05)。依据患者CMI水平三分位分组,随着CMI水平的升高,其腰围、臀围、腰臀比、收缩压、内脏脂肪面积、皮下脂肪面积、甘油三酯、Oh胰岛素、Oh及2 h血糖、HOMA-IR、BMI等水平均呈升高趋势,高密度脂蛋白呈递减趋势,差异有统计学意义(P<0.05);三组的年龄、胆固醇、低密度脂蛋白、糖化血红蛋白、2h胰岛素水平比较,差异无统计学意义(P>0.05)o Q1组、Q2组、Q3组的糖代谢异常率分别为14.7%、34.7%、54.5%,三组比较,差异有统计学意义(P<0.05)。Pearson相关性分析显示,CMI与腰围、收缩压、内脏脂肪、皮下脂肪、甘油三酯、空腹胰岛素、OGTT 2 h胰岛素、空腹血糖、OGTT 2 hM糖、HOMA-IR、BMI呈正相关(P<0.05),与高密度脂蛋白呈负相关(P<0.05)。Logistic回归分析显示CMI升高是GDM患者产后糖代谢异常的危险因素(OR=15.821,95%C7•:1.402,178.423,P=0.025)。结论CMI可在一定�
Objective To investigate the relationship between cardiac metabolic index(CMI)and abnormal glucose metabolism in patients with gestational diabetes mellitus(GDM)1 year after delivery.Methods A total of 102 GDM patients who gave birth in the Obstetrics Department of our hospital were selected as the research objects and followed up for 1 year after delivery.According to the results of 75 g oral glucose tolerance test(OGTT),the patients were divided into abnormal glucose metabolism group and normal glucose metabolism group.The clinical indicators of the two groups were compared.Further according to CMI level,GDM patients were divided into QI group,Q2 group and Q3 group according to the quantile method.The clinical indicators and the prevalence of abnormal glucose metabolism were compared among the three groups.Pearson correlation analysis was used to analyze the correlation between CMI and clinical indicators,and Logistic multivariate regression was used to analyze the influencing factors of postpartum glucose metabolism abnormalities in GDM patients.Results Compared with the normal glucose metabolism group,the waist circumference,systolic blood pressure,diastolic blood pressure,visceral fat area,triglyceride,glycosylated hemoglobin,fasting blood glucose and insulin levels,2 h blood glucose and insulin levels,homeostasis model assessment-insulin resistance(HOMA-IR),CMI and body mass index(BMI)in the abnormal glucose metabolism group were higher at 1 year after delivery,and the differences were statistically significant(P<0.05);there were no significant differences in age,subcutaneous fat area,cholesterol,high density lipoprotein and low density lipoprotein levels between the two groups(P>0.05).The patients were grouped according to the third of CMI level.With the increase of CMI level,the waist circumference,hip circumference,waist-hip ratio,systolic blood pressure,visceral fat area,subcutaneous fat area,triglyceride,0 h insulin,0 h and 2 h blood glucose,HOMA-IR,and BMI showed an increasing trend,while high-density
作者
伍冬梅
王烈林
唐超燕
党超志
罗瑞琼
张萍
Wu Dongmei;WangLielin;Tang Chaoyan;Dang Chaozhi;Luo Ruiqiong;Zhang Ping(Department of Endocrinology,Yulin First People's Hospital,Tulin 537000,China)
出处
《实用妇科内分泌电子杂志》
2022年第11期9-13,共5页
Electronic Journal of Practical Gynecological Endocrinology
基金
玉林市科学研究与技术开发计划(编号201934047)。
关键词
妊娠期糖尿病
心脏代谢指数
糖代谢异常
Gestational diabetes mellitus
Cardiometabolic index
Glucose metabolism abnormalities
