摘要
目的探究不同磁共振成像(MRI)序列构建的影像组学标签(Radscore)对于术前评估脑胶质瘤高低级别分级的诊断效能差异。方法回顾性纳入郑州大学第二附属医院,河南省肿瘤医院和河南省中医院2015年5月至2020年12月经临床确诊脑胶质瘤的患者,郑州大学第二附属医院入组患者均于术前行MRI[TWI,TWI,扩散加权成像(DWI),增强TWI(TWI-CE)]扫描,基于TWI序列对患者的病灶进行3D分割,分割后将感兴趣区(ROI)映射至TWI,DWI。基于TWI,TWI,DWI序列分别提取影像组学参数后,将入组患者按7∶3比例分为训练组和测试组。采用最小冗余最大相关(mRMR)对训练组患者进行特征降维,采用套索算法(LASSO)构建Radscore,最后采用受试者工作特征曲线(ROC)评估不同序列构建Radscore对脑胶质瘤高低级别分级的诊断效能。将河南省肿瘤医院与河南省中医院入组患者作为外部验证患者,按照不同序列构建Radscore计算外部验证患者的Radscore得分,并采用ROC评估不同序列构建Radscore的诊断效能。结果训练组患者TWI,TWI,DWI序列提取影像组学特征经过去冗除杂后,分别保留11、13、9个参数构建Radscore_TWI,Radscore_TWI,Radscore_DWI,训练组和测试组低级别脑胶质瘤患者Radscore均低于高级别脑胶质瘤患者Radscore,且差异具有统计学意义(P<0.05)。Radscore_TWI,Radscore_TWI,Radscore_DWI在训练组和测试组中的诊断效能均>0.90,且特异性、敏感性均较好,ROC进Delong检验,无统计学差异(P>0.05)。外部验证中,两个中心的患者数据均显示Radscore_TWI,Radscore_TWI,Radscore_DWI的曲线下面积(AUC)无统计学差异。结论不同序列的MRI构建单序列Radscore对脑胶质瘤患者的不同级别的诊断效能无显著差异。
Objective To explore the difference in the diagnostic efficacy of the Radscore constructed by different Magnetic resonance imaging sequences for the preoperative evaluation the stage of glioma.Method Patients clinically diagnosed with glioma in our hospital from May 2015 to December 2020 were retrospectively enrolled.All patients underwent MRI(TWI,TWI,DWI,TWI-CE)scan before surgery.The lesions of the patients were 3 D segmented based on TWI sequence,and the ROI was mapped to TWI-DWI after segmentation.Radiomics parameters were extracted from TWI,TWI and DWI respectively,and patients were then divided into training group and test group in a 7∶3 ratio.mRMR was used to carry out feature dimension reduction for patients in the training group,and the radiomics signature(Radscore)was constructed by Lasso.Finally,receiver operating characteristic curve was used to evaluate the diagnostic efficacy of different sequences constructed Radscore for the grade of glioma.Result Radiomics features were extracted from TWI,TWI and DWI of patients from training group.After removal of redundancy,11,13 and 9 parameters were retained to construct Radscore_TWI,Radscore_TWI,and Radscore_DWI,respectively.Radscore of patients with low-grade glioma in training group and test group was lower than that of patients with high-grade glioma,and the difference was statistically significant(P<0.05).The diagnostic efficacy of Radscore_TWI,Radscore_TWI and Radscore_DWI in both the training group and the test group was>0.90.Delong showed no significant in ROC among Radscore_TWI,Radscore_TWI,and Radscore_DWI.Conclusion The single sequence Radscore constructed by MRI with different sequences has good diagnostic efficacy for different grades of glioma patients.
作者
阮君
张晓琦
刘文涛
韩萌
RUAN Jun;ZHANG Xiaoqi;LIU Wentao(Department of Radiology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province 450014,P.R.China)
出处
《临床放射学杂志》
北大核心
2022年第8期1408-1415,共8页
Journal of Clinical Radiology
