摘要
目的探讨贝前列素钠联合Epley法在后半规管良性阵发性位置性眩晕(bengin paroxysmal positional vertigo,BPPV)治疗中的临床疗效。方法选择2019年1月至2020年12月我院神经内科门诊就诊的338例后半规管BPPV患者,随机分为3组,观察组为手法复位治疗联合口服贝前列素钠组118例、对照组1为单纯手法复位治疗组114例、对照组2为手法复位治疗联合口服甲磺酸倍他司汀组106例,对比3组患者的临床治疗效果、前庭症状指数(vestibular symptom index,VSI)评分、眩晕障碍量表(dizziness handicap inventory,DHI)评分和复发率上的差异。结果治疗后1 w观察组总有效率为91.53%,高于对照组1的73.68%和对照组2的86.79%,差异具有统计学意义(P<0.05);3组患者治疗后1 w及1 m的前庭症状指数评分(VSI)、眩晕障碍量表评分(DHI)均较治疗前明显下降,但观察组下降的幅度更明显,差异具有统计学意义(P<0.05);治疗后3 m内观察组复发率均低于对照组1和对照组2,分别为观察组18.64%、对照组1的34.21%和对照组2的27.36%,差异有统计学意义(P<0.05)。结论手法复位治疗联合口服贝前列素钠治疗后半规管BPPV的临床疗效优于单纯手法复位治疗和手法复位治疗联合口服甲磺酸倍他司汀治疗后半规管BPPV。
Objective To study the clinical effects of beprost sodium tablets combined with Epley manual reduction in treatment of benign paroxysmal positional vertigo(BPPV).Methods A total of 338 patients with posterior semicircular canal BPPV who were treated in the neurogy clinic of our hospital from January 2019 to December 2020 were enrolled in the study,who were randomly divided into the observation group,who were treated in Epley manual reduction combined with oral beprost sodium tablets,118 cases;control group 1,who were treated with only Epley manual reduction,114 cases and control group 2,who were treated with Epley manual reduction combined with oral betahistine mesilate tablets,106 cases.The clinical efficacy,vestibular symptom index(VSI),dizziness handicap inventory(DHI)and relapse rate were observed and compared between the three groups.Results The total effective rate in the observation group was 91.53%,which was significantly higher than that(73.68)in control group1 and(86.79%)in control group2,the difference was statistically significant(P<0.05).One week and one month After manual reduction,the vestibular symptom index(VSI)scores and the dizziness handicap inventory(DHI)scores in three group were significantly lower than pre-treatment,moreover,the decrease degree in the observation group was more significant than the other two control groups,the difference was statistically significant(P<0.05).Within 3 months after treatment,the relapse rate in the observation group(18.64%)was lower than that in control group1(34.21%)and in control group2(27.36%),the difference was statistically significant(P<0.05).Conclusion The clinical effects of beprost sodium tablets combined with Epley manual reduction in treatment of posterior semicircular canal BPPV are superior to those by simple Epley manual reduction and by Epley manual reduction combined with betahistine mesilate.
作者
贾伟
刘晓微
李召晨
王玉平
JIA Wei;LIU Xiaowei;LI Zhaochen(Department of Neurology,Beijing Huairou Hospital,9 Yongtai North Street of Huairou District,Beijing 101400,China)
出处
《中风与神经疾病杂志》
CAS
2022年第9期813-817,共5页
Journal of Apoplexy and Nervous Diseases
关键词
贝前列素钠
甲磺酸倍他司汀
良性阵发性位置性眩晕
手法复位
疗效
Beprost sodium
Betahistine mesylate
Benign paroxysmal positional vertigo
Manual reduction
Clinical effects
