摘要
目的 探讨2型糖尿病(T2DM)合并大血管病变老年患者血清摄食抑制因子1 (nesfatin-1)、腓骨蛋白-1 (Fibulin-1)水平与血脂及胰岛素抵抗的关系。方法 选择2018年1月至2019年10月陕西省人民医院收治的T2DM老年患者120例,其中单纯T2DM患者74例设为单纯T2DM组,合并大血管病变的T2DM患者46例设为合并组,另取同期健康体检者50例设为对照组。检测并比较各组受检者的血清nesfatin-1、Fibulin-1、血脂及胰岛素抵抗相关指标水平,采用Pearson相关性分析T2DM合并大血管病变患者血清nesfatin-1、Fibulin-1水平与血脂及胰岛素抵抗的相关性。结果 合并组患者的血清nesfatin-1、Fibulin-1、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平[(12.36±2.02)μg/L、(18.27±4.14)μg/mL、(5.42±0.96) mmol/L、(2.87±0.89) mmol/L、(3.21±0.92) mmol/L]明显高于单纯T2DM组[(7.44±1.95)μg/L、(10.51±2.76)μg/mL、(4.88±0.82) mmol/L、(2.12±0.73) mmol/L、(2.12±0.73) mmol/L]和对照组[(5.13±1.33)μg/L、(7.83±2.15)μg/mL、(4.18±0.56) mmol/L、(1.17±0.63) mmol/L、(2.01±0.72)mmol/L],而单纯T2DM组又明显高于对照组,差异均有统计学意义(P<0.05);合并组患者的高密度脂蛋白胆固醇(HDL-C)水平为(1.22±0.21) mmol/L,明显低于单纯T2DM组的(1.63±0.32) mmol/L和对照组的(2.03±0.35) mmol/L,而单纯T2DM组又明显低于对照组,差异均具有统计学意义(P<0.05);合并组和单纯T2DM组患者的空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)及胰岛素抵抗指数(HOMA-IR)水平[(10.33±2.42) mmol/L、(10.11±2.53) mmol/L;(15.37±3.91) mU/L、(14.67±3.91) mU/L];[(9.96±2.01)%、(9.04±1.87)%;(7.06±1.42)、(6.59±1.37)]明显高于对照组[(5.15±0.83) mmol/L、(7.69±2.42) m U/L、(5.12±0.44)%、(1.76±0.42)],差异均有统计学意义(P<0.05),但合并组与单纯T2DM组间的上述指标比较差异均无统计学意义(P>0.05);经Pearson相关性分析结果显示,T2DM合并大血管病变患�
Objective To investigate the relationship between serum nesfatin-1,Fibulin-1 levels and blood lipid,insulin resistance in elderly patients with type 2 diabetes mellitus(T2DM) complicated with macrovascular disease.Methods A total of 120 elderly patients with T2DM admitted to Shaanxi Provincial People’s Hospital from January2018 to October 2019 were selected,of which 74 patients with simple T2DM were enrolled as the simple T2DM group and 46 patients with T2DM complicated with macrovascular disease were set as the combined group.Another 50 healthy subjects in the same period were set as the control group.The levels of serum nesfatin-1,Fibulin-1,blood lipid and insulin resistance in each group were detected and compared.The correlation between serum nesfatin-1,Fibulin-1 levels and blood lipid and insulin resistance in patients with T2DM complicated with macrovascular disease were analyzed according to Pearson correlation.Results The levels of serum nesfatin-1,Fibulin-1,total cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C) in combined group were(12.36±2.02) μg/L,(18.27±4.14) μg/mL,(5.42±0.96) mmol/L,(2.87±0.89) mmol/L,(3.21±0.92) mmol/L,which were significantly higher than(7.44±1.95) μg/L,(10.51±2.76) μg/mL,(4.88±0.82) mmol/L,(2.12±0.73) mmol/L,(2.12±0.73) mmol/L in simple T2DM group and(5.13±1.33) μg/L,(7.83±2.15) μg/mL,(4.18±0.56) mmol/L,(1.17±0.63) mmol/L,(2.01±0.72) mmol/L in the control group(P0.05).Pearson correlation analysis showed that the levels of serum nesfatin-1 and Fibulin-1 were positively correlated with the levels of TC,TG,LDL-C,FPG,FINS,HbA1c,and HOMA-IR,but negatively correlated with the level of HDL-C(P<0.05).Conclusion The levels of serum nesfatin-1 and Fibulin-1 in elderly patients with T2DM complicated with macrovascular disease are abnormally increased,which are related to blood lipid and insulin resistance.The detection of serum nesfatin-1 and fibulin-1 levels has a certain clinical value for the diagnosis of T2DM complicated with macrova
作者
王甜
吴华
刘娅萍
WANG Tian;WU Hua;LIU Ya-ping(Ward One,West Hospital,Shaanxi Provincial People's Hospital,Xi'an 710068,Shaanxi,CHINA;Institute of Chronic Diseases,Shaanxi Center for Disease Control and Prevention,Xi'an 710054,Shaanxi,CHINA)
出处
《海南医学》
CAS
2022年第19期2483-2487,共5页
Hainan Medical Journal
