摘要
目的 本研究拟探讨重组人表皮生长因子外用溶液联合蒙脱石散保留灌肠预防宫颈癌患者急慢性放射性直肠炎的疗效,为防治放射性直肠炎提供有效方案。方法 收集59例根治性放疗的宫颈癌患者,随机分成对照组28例,灌肠组31例;灌肠组给重组人表皮生长因子外用溶液联合蒙脱石散保留灌肠,对照组无灌肠处理。结果 在急性放射性直肠炎方面,两组患者消化道反应分级分布相似,主要以0~2级为主,比较差异无统计学意义(U=429.5,P=0.939)。在慢性直肠炎方面,灌肠组维也纳直肠镜(vienna rectoscopy score,VRS)分项评分及总评分的轻度反应(0~1级)患者明显高于对照组,而对照组中度反应(2~3级)的患者明显增多;两组毛细血管扩张(U=262.5,P=0.003)、黏膜充血(U=256,P=0.002)及总VRS评分(U=256,P=0.002)差异有统计学意义。结论 重组人表皮生长因子外用溶液联合蒙脱石散保留灌肠可减低宫颈癌根治性放疗患者慢性直肠炎的发生率及严重程度。
Objective Retention enema is a simple and effective method for preventing and treating radiation proctitis(RP),while there is no standard regimen. This study aims to investigate the effectiveness of recombinant human epidermal growth factor derivative for external use combined with smectite powder administrated by retention enema for the prevention of RP in cervical cancer patients. Method Fifty-nine patients with cervical cancer treated with radical radiotherapy were collected and randomly divided into control group(n = 28)and enema group(n = 31). The enema group was given recombinant human epidermal growth factor derivative for external use combined with smectite powder by retention enema,while the control group did not receive enema administration.Results Gastrointestinal adverse reaction of the two groups was similar with grade 0-2,and there was no statistical difference between two groups(U = 429.5,P = 0.939)in acute PR. In terms of chronic PR,the sub-item score and total score of Vienna Rectoscopy Score(VRS)showed that there were more patients with mainly mild adverse events(grade 0 ~ 1)in enema group,while there were significantly more patients with moderate adverse events(grade 2 ~ 3)in the control group. Capillary telangiectasia(U = 262.5,P = 0.003),mucosal hyperemia(U = 256,P = 0.002)and VRS total score(U = 256,P = 0.002)were statistically different in the two groups. Conclusion Recombinant human epidermal growth factor derivative for external use combined with smectite powder administrating by retention enema could reduce the incidence and severity of chronic PR in patients with radical radiotherapy for cervical cancer.
作者
李洲宇
杨兴龙
蔡展拓
朱艳仪
覃青华
李铭仪
LI Zhouyu;YANG Xinglong;CAI Zhantuo;ZHU Yanyi;QIN Qinghua;LI Mingyi(Department of Radiation Oncology,Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China)
出处
《实用医学杂志》
CAS
北大核心
2022年第17期2221-2225,共5页
The Journal of Practical Medicine
基金
广州市科技局项目(编号:202102010093)。
关键词
表皮生长因子
蒙脱石散
保留灌肠
宫颈癌
放射性直肠炎
human epidermal growth factor
smectite powder
retention enema
cervical cancer
radiation proctitis
