摘要
【目的】在岭南地区拟建万人自然队列,了解万人队列基本特征并分析岭南湿性体质对重大慢性非传染性疾病的影响因素,为进一步开展正式流行病学调查提供参考。【方法】采用回顾性队列研究方法,选取2018年1月至2020年12月于某健康管理中心体检的人群进行数据采集,包括问卷调查、体格检查、实验室检测和影像学检查结果,定义2018年为基线,统计分析该人群慢性非传染性疾病发生、发展情况,同时分析该人群中医体质分布情况、湿性体质与代谢综合征和心脑血管疾病的关联情况。【结果】(1)纳入统计人群共41817例,平均年龄为(46.6±12.9)岁,男性占65.41%,女性占34.59%;慢性疾病患病率分别为恶性肿瘤0.24%、冠心病1.03%、高血压病28.80%、高脂血症68.94%、糖尿病6.85%和代谢综合征11.05%。(2)基线人群中医体质调查共2830例,其中男性1184例(41.84%),女性1646例(58.16%),湿性体质(包括湿热质和痰湿质)占42.76%(1210/2830)。统计结果发现,与非湿性体质(湿热质和痰湿质以外的7种体质相加)人群相比,湿性体质人群的肥胖、腹型肥胖和代谢综合征的患病率更高,差异均有统计学意义(P<0.001);非条件逐步Logistic回归分析结果显示,湿性体质、痰湿体质与代谢综合征呈正相关关系,代谢综合征与心脑血管疾病呈正相关关系。【结论】岭南地区自然人群的慢性疾病患病率、湿性体质人群的分布比重均有别于其他地区,且分析发现湿性体质与代谢综合征的患病有密切关联,但具体的因果关系有待后续建前瞻性队列进行探索研究。
Objective To explore the basic characteristics of the cohort of over 10000 natural people in Lingnan area and to investigate the influencing factors of damp constitution on major chronic non-communicable diseases,so as to provide a reference for performing formal epidemiological investigation.Methods A retrospective cohort study was conducted in the population who underwent physical examination in a health management center of Lingnan area from January 2018 to December 2020.We collected the data of questionnaire survey,physical examination,laboratory test and imaging examination results.With the data of the year of 2018 as the baseline,the occurrence and progression of chronic non-communicable diseases in this population were statistically analyzed.Meanwhile,the distribution of traditional Chinese medicine(TCM)constitution and the correlation of damp constitution and metabolic syndrome with cardio-cerebrovascular diseases in this population were also analyzed.Results(1)A total of 41817 subjects were included in the study,with an average age of(46.6±12.9)years old,and the male accounted for 65.41%and the female accounted for 34.59%.The chronic diseases included malignant tumor,coronary heart disease,hypertension,hyperlipidemia,diabetes and metabolic syndrome,and their prevalence accounted for 0.24%,1.03%,28.80%,68.94%,6.85%and 11.05%,respectively.(2)A total of 2830 cases in baseline population participated into the TCM constitution investigation,of which1184 cases(41.84%)were male and 1646(58.16%)were female,and 42.76%of the cases were identified as damp constitution(including damp-heat constitution and phlegm-damp constitution,1210/2830).The results showed that the prevalence of obesity,abdominal obesity and metabolic syndrome was higher in the damp constitution group than that in the non-damp constitution group(including the seven constitutions except dampheat constitution and phlegm-damp constitution),and the differences were statistically significant(P<0.001).The results of non-conditional stepwise Logistic r
作者
陈延佳
龚宝莹
黄鹂
原嘉民
欧爱华
翁衡
梁咏竹
罗翠文
郝艺照
郭建文
孟琳
杨志敏
CHEN Yan-Jia;GONG Bao-Ying;HUANG Li;YUAN Jia-Min;OU Ai-Hua;WENG Heng;LIANG Yong-Zhu;LUO Cui-Wen;HAO Yi-Zhao;GUO Jian-Wen;MENG Lin;YANG Zhi-Min(Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120 Guangdong,China;Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine,Zhuhai 519015 Guangdong,China;The Eleventh People’s Hospital of Guangzhou,Guangzhou 510530 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2022年第9期1957-1963,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
省部共建中医湿证国家重点实验室(广州中医药大学第二附属医院)项目(编号:SZ2021ZZ06,SZ2021ZZ30,SZ2021ZZ31,SZ2021ZZ32)。
关键词
回顾性队列研究
湿性体质
代谢综合征
心脑血管疾病
慢性非传染性疾病
岭南地区
retrospective cohort study
damp constitution
metabolic syndrome
cardio-cerebrovascular diseases
chronic non-communicable disease
Lingnan region
