摘要
【目的】探究五藤治尪汤加味联合塞来昔布治疗强直性脊柱炎湿热痹阻证患者的临床疗效。【方法】采用回顾性研究方法,收集2019年10月~2020年10月在深圳市中医院就诊的64例强直性脊柱炎湿热痹阻证患者,根据是否接受五藤治尪汤加味治疗,将患者分为试验组和对照组,每组各32例。对照组给予内服塞来昔布治疗,试验组给予五藤治尪汤加味联合塞来昔布治疗。4周为1个疗程,共治疗2个疗程。观察2组患者治疗前后疼痛视觉模拟量表(VAS)评分、巴氏强直性脊柱炎功能指数(BASFI)评分、巴氏强直性脊柱炎疾病活动指数(BASDAI)评分、强直性脊柱炎总和指数(BAS-G)评分以及腰椎关节活动度(包括前屈、后伸等)的变化情况,评价2组患者的中医证候疗效及安全性。【结果】(1)治疗期间共有4例患者脱落,最终共有60例患者完成全部疗程的治疗,其中试验组和对照组各30例。(2)治疗8周后,试验组的总有效率为93.33%(28/30),对照组为56.67%(17/30),组间比较,试验组的中医证候疗效明显优于对照组(P<0.05)。(3)治疗后,2组患者的疼痛VAS评分均较治疗前明显降低(P<0.05),但治疗后组间比较,差异无统计学意义(P>0.05)。(4)治疗后,2组患者的BASFI评分、BASDAI评分和BAS-G评分均较治疗前明显降低(P<0.05),且试验组的降低作用均明显优于对照组(P<0.05)。(5)治疗后,2组患者的前屈、后伸等腰椎关节活动度均较治疗前明显改善(P<0.05),且试验组的改善作用均明显优于对照组(P<0.05)。(6)治疗过程中,除4例因胃肠副作用较大而脱落外,其余患者均无明显的不良反应发生,且患者的尿常规、血常规、肝肾功能等安全性指标均无异常改变。【结论】五藤治尪汤加味联合塞来昔布治疗强直性脊柱炎湿热痹阻证患者疗效确切,其疗效明显优于单纯运用塞来昔布治疗。
Objective To explore the clinical efficacy of flavored Wuteng Zhiwang Decoction combined with Celecoxib Tablets in treating patients with damp-heat blockage type of ankylosing spondylitis(AS).Methods A retrospective study was conducted for 64 patients with damp-heat blockage type of AS who attended Shenzhen Traditional Chinese Medicine Hospital from October 2019 to October 2020.According to the medication of flavored Wuteng Zhiwang Decoction or not,the patients were divided into the trial group and the control group,with32 patients in each group.The control group was treated with oral use of Celecoxib Tablets,while the trial group was treated with flavored Wuteng Zhiwang Decoction combined with Celecoxib Tablets.The patients in both groups were given two courses of treatment and four weeks constituted a course of treatment.The changes in pain visual analogue scale(VAS)scores,Bath Ankylosing Spondylitis Functional Index(BASFI)scores,Bath Ankylosing Spondylitis Disease Activity Index(BASDAI)scores,Bath Ankylosing Spondylitis Patient Global Score(BAS-G)scores and lumbar joint range of motion(including anterior flexion and posterior extension)in the two groups were observed.After treatment,the TCM syndrome efficacy and clinical safety in the two groups were evaluated.Results(1)Four patients fell off during the treatment,and a total of 60 patients eventually completed the full course of treatment,including 30 cases in the trial group and 30 cases in the control group.(2)After 8 weeks of treatment,the overall effective rate in the trial group was 93.33%(28/30)and that in the control group was 56.67%(17/30),and the intergroup comparison showed that the TCM syndrome efficacy in the trial group was significantly superior to that in the control group(P<0.05).(3)After treatment,the pain VAS scores of patients in both groups were significantly decreased compared with those before treatment(P<0.05),but the difference was not statistically significant between the two groups after treatment(P>0.05).(4)After treatment,the BASFI
作者
鄢博纳
张应生
何升华
YAN Bo-Na;ZHANG Ying-Sheng;HE Sheng-Hua(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518000 Guangdong,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518000 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2022年第10期2268-2272,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:82174397)
广东省中医药局科研项目(编号:20191276)。
关键词
五藤治尪汤
塞来昔布
强直性脊柱炎
湿热痹阻证
疗效观察
Wuteng Zhiwang Decoction
Celecoxib Tablets
ankylosing spondylitis(AS)
damp-heat blockagesyndrome
clinical efficacy observation
