摘要
目的评价金莲花制剂(金莲花颗粒,金莲花片)对比其他药物(利巴韦林,复方草珊瑚含片)治疗上呼吸道感染临床疗效的有效性。方法通过计算机检索中国知网、维普网、万方数据、中国生物医学文献数据、PubMed、Cochrane Library从建库至2020年8月30日文献,搜集所有关键词含金莲花和上呼吸道感染的研究,按照纳入与排除标准筛选文献并提取数据,按照RevMan5.3软件的Cochrane系统评价进行研究质量评价,用RevMan5.3软件对纳入文献的研究进行Meta分析。结果纳入7篇相关临床试验研究,共计1178例病例,Meta分析结果显示,实验组(金莲花颗粒联合利巴韦林,金莲花片)治疗上呼吸感染的总有效率OR=5.51,95%CI=[2.61~11.63],P<0.00001;OR=1.80,95%CI=[1.08~2.99],P=(0.02<0.05)分别高于对照组(利巴韦林,复方草珊瑚含片)的总有效率。结论金莲花颗粒及金莲花片等金莲花中成药对上呼吸道感染的临床疗效优于其他药物,临床可以考虑推广应用。但由于此次研究纳入研究样本较少,纳入的研究偏倚风险较高,此结论需要更多高质量、多中心、大样本的随机实验进一步验证。
Objective To evaluate the efficacy of Chinese patent medicines related to Trollius chinensis(Trollius granules,Trollius tablets)as against other drugs(ribavirin,Fufang Caoshanhu Hanpian)in the treatment of upper respiratory tract infections.Methods Related literature was searched for and collected from PubMed,Cochrane Library,CBM,CNKI,VIP and Wangfang database from inception to August 30,2020 with Trollius chinensis and upper respiratory tract infection as the keywords.Literature was screened and data was extracted according to the inclusion and exclusion criteria.Rev Man5.3 software was used for assessment of the risk of bias of the included studies and for data analysis.Results Seven randomized controlled trials were included involving 1178 patients totally.The result of Meta analysis showed that the total effective rates of experimental groups(Trollius granules and Trollius tablets)against upper respiratory tract infections were higher than those of the control groups(ribavirin and Fufang Caoshanhu Hanpian)respectively.Conclusion Such patent Chinese medicines as Trollius granules and Trollius tablets have better clinical efficacy against upper respiratory tract infections than other drugs and clinical application could be considered.However,the samples of the included studies are not enough and the included studies have a higher risk of bias.This conclusion needs to be further verified by more high-quality,multi-center,large-sample random experiments.
作者
林琦琪
赵楠
孙琦
王琳
孟繁浩
LIN Qiqi;ZHAO Nan;SUN Qi;WANG Lin;MENG Fanhao(School of Pharmacy,China Medical University,Shenyang Liaoning 110122,China)
出处
《中国药物警戒》
2022年第8期893-896,907,共5页
Chinese Journal of Pharmacovigilance
基金
辽宁省自然科学基金资助项目(201602880)。
关键词
金莲花
上呼吸道感染
META分析
Trolliius chinensis
upper respiratory tract infection
Meta analysis
