摘要
目的分析郭补林名中医自拟加味生地六味汤联合常规西药治疗气阴两虚型糖尿病肾病(DKD)的效果及对T细胞亚群、肾纤维化指标的影响。方法选取2020年1月至2021年5月我院收治的82例气阴两虚型DKD患者作为研究对象,将其随机分为对照组与观察组,每组41例。对照组以常规西药治疗,观察组在对照组基础上联用郭补林名中医自拟的加味生地六味汤治疗。比较两组的糖代谢、肾功能、T细胞亚群及肾纤维化指标。结果治疗后,两组的血清空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及血清糖化血红蛋白(HbA1c)均降低,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的血清血肌酐(Scr)、血清尿素氮(BUN)、尿酸(UA)、血清肾损伤分子-1(KIM-1)水平均降低,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的全血白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))及白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))均升高,且观察组明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的血清Ⅳ型胶原(CⅣ)、Ⅲ型前胶原肽(PⅢP)、层粘连蛋白(LN)、转化生长因子-β_(1)(TGF-β_(1))水平均降低,且观察组明显低于对照组(P<0.05)。结论郭补林名中医自拟的加味生地六味汤联合常规西药治疗气阴两虚型DKD的效果显著,可显著改善患者的糖代谢情况及肾功能,提高免疫功能,延缓肾脏纤维化进展速度。
Objective To analyze the effect of modified Shengdi Liuwei decoction self-prepared by famous TCM physician Guo Bulin combined with conventional western medicine in the treatment of diabetic kidney disease(DKD)with deficiency of Qi-Yin and its influences on T cell subsets and renal fibrosis indexes.Methods A total of 82 DKD patients with deficiency of Qi-Yin admitted in our hospital from January 2020 to May 2021 were selected as the study objects,and the patients were randomly divided into control group and observation group,with 41 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with modified Shengdi Liuwei decoction self-prepared by famous TCM physician Guo Bulin on the basis of the control group.The indexes of glucose metabolism,renal function,T cell subsets and renal fibrosis were compared between the two groups.Results After treatment,the levels of serum fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2 h PG)and glycated hemoglobin(HbA1c)in the two groups decreased,and those in the observation group were significantly lower than the control group,the differences were stastistically significant(P<0.05).After treatment,the levels of serum creatinine(Scr),serum urea nitrogen(BUN),uric acid(UA)and serum kidney injury molecule-1(KIM-1)in the two groups decreased,and those in the observation group were significantly lower than the control group,the differences were stastistically significant(P<0.05).After treatment,the whole blood cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 4 positive(CD4^(+))and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+))in the two groups increased,and those in the observation group were significantly higher than the control group,the differences were stastistically significant(P<0.05).After treatment,the levels of serum collagen Ⅳ(CⅣ),procollagen Ⅲ peptide(PⅢP),laminin(LN)and transforming growth factor-β_(1)(TGF-β_(1))
作者
刘旭琴
赵崇霞
郭补林
赵亚峰
郭亚平
鲁小庆
赵东艳
LIU Xuqin;ZHAO Chongxia;GUO Bulin;ZHAO Yafeng;GUO Yaping;LU Xiaoqing;ZHAO Dongyan(Traditional Chinese Medicine Hospital of Yulin,Yulin 719000,China)
出处
《临床医学研究与实践》
2022年第28期137-140,共4页
Clinical Research and Practice
基金
榆林市科协青年人才托举计划项目(No.20200225)。
关键词
糖尿病肾病
加味生地六味汤
糖代谢
肾功能
T细胞亚群
肾纤维化
diabetic kidney disease
modified Shengdi Liuwei decoction
glucose metabolism
renal function
T cell subsets
renal fibrosis
