摘要
目的探讨七氟烷复合右美托咪定麻醉在老年骨折患者中的应用效果及对认知功能障碍发生情况的影响。方法选择2018年1月至2020年12月我院收治的60例老年骨折患者作为研究对象,根据麻醉方案不同将其分为观察组(30例,七氟烷复合右美托咪定麻醉)与对照组(30例,七氟烷麻醉)。比较两组的认知功能障碍发生情况、应激、炎症反应指标、S100β蛋白水平。结果术后1、2 d,观察组的认知功能障碍发生率低于对照组(P<0.05);术后3 d,两组的认知功能障碍发生率无显著差异(P>0.05)。术后1 d,观察组的去甲肾上腺素(NE)、肾上腺素(E)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。术后1、2 d,观察组的S100β蛋白水平低于对照组(P<0.05)。结论七氟烷复合右美托咪定麻醉方案在老年骨折患者中的应用效果显著,可防止患者发生认知功能障碍,改善应激反应指标及S100β蛋白水平。
Objective To investigate the application effect of sevoflurane combined with dexmedetomidine anesthesia in elderly patients with fracture and its influence on the occurrence of cognitive dysfunction.Methods Sixty elderly patients with fracture admitted in our hospital from January 2018 to December 2020 were selected as the research objects.According to different anesthesia schemes,the patients were divided into observation group(30 cases,sevoflurane combined with dexmedetomidine anesthesia)and control group(30 cases,sevoflurane anesthesia).The occurrence of cognitive dysfunction,stress response and inflammation indexes and S100βprotein level were compared between the two groups.Results At 1 and 2 d after operation,the incidence of cognitive dysfunction in the observation group was lower than that in the control group(P<0.05);there was no significant difference in the incidence of cognitive dysfunction between the two groups at 3 d after operation(P>0.05).At 1 d after operation,the levels of norepinephrine(NE),epinephrine(E),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).At 1 and 2 d after operation,the level of S100βprotein in the observation group was lower than that in the control group(P<0.05).Conclusion Sevoflurane combined with dexmedetomidine anesthesia in elderly patients with fracture has a significant application effect,which can prevent cognitive dysfunction,and improve stress response indicators and S100βprotein levels.
作者
李艳磊
张继洛
LI Yanlei;ZHANG Jiluo(Anesthesiology Department,Xinxiang Huangta Orthopedic Hospital/Huaxian Department of Orthopedics Hospital,Xinxiang 456485;Anesthesiology Department,Henan Provincial Orthopedic Hospital,Zhengzhou 450000,China)
出处
《临床医学研究与实践》
2022年第28期101-103,共3页
Clinical Research and Practice
关键词
七氟烷
右美托咪定
老年患者
骨折
认知功能障碍
sevoflurane
dexmedetomidine
elderly patients
fracture
cognitive dysfunction
