摘要
目的:分析恩替卡韦治疗慢性乙型肝炎的效果。方法:选取湖南省第二人民医院2019年7月-2020年9月收治的84例慢性乙型肝炎患者作为研究对象,随机分为两组,各42例。观察组应用恩替卡韦治疗,对照组应用阿德福韦酯治疗。比较两组治疗效果。结果:治疗后,观察组碱性磷酸酶(ALP)、谷丙转氨酶(ALT)及总胆红素(TBiL)水平均低于对照组,差异有统计学意义(P<0.05)。观察组双歧杆菌水平高于对照组,梭菌、肠杆菌及肠球菌水平低于对照组,差异有统计学意义(P<0.05)。两组治疗1个月后,乙型肝炎e抗原、乙型肝炎病毒DNA转阴率比较,差异无统计学意义;观察组治疗2、3个月后,乙型肝炎e抗原、乙型肝炎病毒DNA转阴率均高于对照组,差异有统计学意义(P<0.05)。结论:给予慢性乙型肝炎患者恩替卡韦治疗,能促进患者肝功能改善,改善肠道菌群水平,提高乙型肝炎病毒DNA、乙型肝炎e抗原转阴率,建议应用并予以推广。
Objective: To observe the effects of entecavir on chronic hepatitis B. Methods: Eighty-four patients with chronichepatitis B who admitted in our hospital from July 2019 to September 2020 were selected and randomly divided into two groups, wit42 cases in each group. The observation group was treated with entecavir and the control group treated with adefovir dipivoxil. Thetreatment effects of two groups were compared. Results: After treatment, the levels of alkaline phosphatase(ALP), alanineaminotransferase(ALT), and total bilirubin(TBi L) in the observation group were lower than those in the control group, and thedifferences were statistically significant(P<0.05). The bifidobacteria level in the observation group was higher than that in thecontrol group, while the levels of Clostridium, Enterobacter and Enterococcus in the observation group were lower than those in thecontrol group, and the differences were statistically significant(P<0.05). After 1 month of treatment, there were no significantdifference in the conversion rates of hepatitis B E antigen and hepatitis B virus DNA between the two groups. After 2 and 3 monthsof treatment, the negative conversion rates of hepatitis B E antigen and hepatitis B virus DNA in the observation group were higherthan those in the control group, and the differences were statistically significant(P< 0.05). Conclusion: Application of entecavir forthe treatment of chronic hepatitis B can promote the improvement of liver function, improve intestinal flora level, and can increasethe negative conversion rates of hepatitis B virus DNA and hepatitis B E antigen, which is recommended to be applied andpromoted.
作者
许若思
Xu Ruo-si(Department of Gastroenterology,Second People's Hospital of Hunan Province(Hunan Provincial Brain Hospital),Changsha 410007,Hunan Province,China)
出处
《中国社区医师》
2022年第26期43-45,共3页
Chinese Community Doctors
