摘要
目的探讨右美托咪定联合地佐辛用于腰椎内固定术后患者的镇痛效果及对患者痛觉过敏的影响。方法选取武警海警总队医院2018年4月至2019年6月择期行腰椎内固定术治疗的患者72例,采用随机数字表法分为对照组、观察组各36例,对照组采用氟比洛芬酯联合地佐辛术后镇痛,观察组采用右美托咪定联合地佐辛术后镇痛。观察两组机械痛觉阈值、术后疼痛程度、并发症发生情况。结果观察组术后6 h、24 h、48 h伤口周围痛觉阈值分别为(119.52±20.42)分、(120.19±17.44)分、(120.94±20.73)分,均高于对照组的(108.42±15.24)分、(107.63±16.83)分、(108.47±17.82)分(t=0.01、0.00、0.01,均P<0.05);观察组术后24 h、48 h前臂痛觉阈值分别为(109.93±15.87)分、(110.79±22.85)分,均高于对照组的(97.07±16.49)分、(95.63±24.06)分(t=3.37、2.74,均P<0.05);两组术后Ramsay评分差异无统计学意义(P>0.05);两组术后48 h内地佐辛使用剂量差异无统计学意义(P>0.05);观察组术后并发症发生率为8.33%(3/36),低于对照组的27.78%(10/36)(χ^(2)=4.60,P<0.05)。结论腰椎内固定术后采用右美托咪定联合地佐辛镇痛效果明显,且可有效预防痛觉过敏,并发症发生率低。
Objective To investigate the analgesic efficacy of dexmedetomidine combined with dizosine after lumbar internal fixation and its effects on hyperalgesia.Methods Seventy-two patients who underwent lumbar internal fixation in General Hospital of Armed Police and Marine Police between April 2018 and June 2019 were included in this study.They were randomly assigned to undergo either flurbiprofen axetil and dizosine administration(control group)or dexmedetomidine and dizosine(observation group)for postoperative analgesia.Mechanical pain,degree of postoperative pain,and incidence of complications were recorded in each group.Results At 6,24 and 48 hours after surgery,peri-wound pain threshold in the observation group was(119.52±20.42)points,(120.19±17.44)points,(120.94±20.73)points,respectively,which were significantly higher than(108.42±15.24)points,(107.63±16.83)points,(108.47±17.82)points in the control group(t=0.01,0.00,0.01,all P<0.05).At 24 and 48 hours after surgery,forearm pain threshold in the observation group was(109.93±15.87)points and(110.79±22.85)points,respectively,which were significantly higher than(97.07±16.49)points and(95.63±24.06)points(t=3.37,2.74,both P<0.05).There was no significant difference in Ramsay Sedation Scale score between the two groups(P>0.05).There was no significant difference in the dose of dizosine used within 48 hours after surgery between the two groups(P>0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group[8.33%(3/36)vs.27.78%(10/36),χ^(2)=4.60,P<0.05].Conclusion Dexmedetomidine combined with dizosine exhibits obvious analgesic efficacy after lumbar internal fixation.The combined therapy can effectively prevent hyperalgesia with a low incidence of comphications.
作者
董玉芳
刘孝国
Dong Yufang;Liu Xiaoguo(Graduate School,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,Zhejiang Province,China;Department of Anesthesiology,General Hospital of Armed Police and Marine Police,Jiaxing 314000,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2022年第9期1297-1301,共5页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省嘉兴市科技计划项目(2017BY18044)。
关键词
麻醉和镇痛
麻醉药
联用
疼痛测定
痛觉过敏
腰椎内固定术
手术后并发症
右美托咪定
地佐辛
Anesthesia and analgesia
Anesthetics,combined
Pain measurement
Hyperalgesia
Lumbar internal fixation
Postoperative complications
Dexmedetomidine
Dizosin
