摘要
目的探讨白细胞介素-21(IL-21)、β_(2)微球蛋白(β_(2)-MG)、白蛋白水平与霍奇金淋巴瘤(HL)患者临床特征和预后的关系。方法选取105例HL患者和82例体检者分别作为观察组和对照组。检测两组受试者血清IL-21、β_(2)-MG、白蛋白水平,比较不同临床特征HL患者血清IL-21、β_(2)-MG、白蛋白水平。随访3年,记录105例HL患者生存情况,HL患者预后的影响因素采用Logistic回归分析。结果观察组患者血清IL-21、白蛋白水平均明显低于对照组,β_(2)-MG水平明显高于对照组,差异均有统计学意义(P﹤0.01)。有淋巴结转移、临床分期为Ⅲ~Ⅳ期HL患者血清IL-21、白蛋白水平分别低于无淋巴结转移和临床分期为Ⅰ~Ⅱ期患者,β_(2)-MG水平分别高于无淋巴结转移和临床分期为Ⅰ~Ⅱ期患者(P﹤0.05)。随访3年,105例HL患者生存75例,死亡30例,病死率为28.57%(30/105)。Logistic回归分析结果显示,IL-21水平降低、β_(2)-MG水平升高、白蛋白水平降低、临床分期为Ⅲ~Ⅳ期、淋巴结转移均是HL患者预后生存的独立危险因素(P﹤0.01)。结论IL-21、β_(2)-MG及白蛋白水平变化均可能与HL的发生、发展有关,可作为HL预后评估的辅助指标。
Objective To investigate the relationship between the levels of interleukin-21(IL-21),β_(2)-microglobulin(β_(2)-MG),albumin and the clinical characteristics and prognosis of patients with Hodgkin’s lymphoma(HL).Method A total of 105 HL patients and 82 physical examination subjects were selected as the observation group and the control group,respectively.The serum levels of IL-21,β_(2)-MG and albumin were detected in the two groups of subjects.The serum levels of IL-21,β_(2)-MG and albumin in HL patients with different clinical characteristics were compared.After 3 years of follow-up,the survival of 105 HL patients was recorded.The prognostic factors of HL patients were analyzed by Logistic regression.Result The serum levels of IL-21 and albumin in the observation group were significantly lower than those in the control group,and the level of β_(2)-MG was significantly higher than that in the control group,and the differences were statistically significant(P<0.01).The serum IL-21 and albumin levels of HL patients with lymph node metastasis and clinical stage Ⅲ-Ⅳ were lower than those without lymph node metastasis and clinical stage Ⅰ-Ⅱ,respectively,and the β_(2)-MG levels were higher than those without lymph node metastasis and clinical stage Ⅰ-Ⅱ,respectively(P<0.05).During the 3-year follow-up,75 of 105 HL patients survived and 30 died,with fatality rate of 28.57%(30/105).Logistic regression analysis showed that IL-21 down-regulation,β_(2)-MG up-regulation,albumin down-regulation,and clinical stage Ⅲ-Ⅳ with lymph node metastasis were independent risk factors for the prognosis and survival of HL patients(P<0.01).Conclusion The overexpression of IL-21,β_(2)-MG and albumin levels may be related to the initial and development of HL,and could be used as auxiliary indicators to judge the prognosis of HL.
作者
韦小婉
沈小卫
尚鹏
卢勇
WEI Xiaowan;SHEN Xiaowei;SHANG Peng;LU Yong(Department of Laboratory Medicine,Ankang Central Hospital,Ankang 725000,Shaanxi,China;Department of Laboratory Medicine,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,Shaanxi,China)
出处
《癌症进展》
2022年第16期1690-1692,1696,共4页
Oncology Progress
