摘要
目的 了解有营养风险的2型糖尿病周围神经病变患者的临床特征。方法 采用营养风险筛查2002(NRS2002)对469例2型糖尿病周围神经病变患者进行营养风险筛查,根据评分结果分为有营养风险组122例和无营养风险组347例。比较两组体重指数(BMI)、血红蛋白(HB)、血清前白蛋白(PA)、血清白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、胱抑素C(CysC)、血尿酸(UA)、糖化血红蛋白(HbA1c)、空腹C肽(FCP)、餐后2小时C肽(2hCP)、住院时间、住院费用,分析2型糖尿病周围神经病变患者发生营养风险的危险因素。结果 469例2型糖尿病周围神经病变患者的营养风险发生率为26.01%,男性的发生率为28.22%,女性的发生率为23.68%,差异无统计学意义(P>0.05);有营养风险组年龄、HbA1c高于无营养风险组,BMI、TG、UA、HB、ALB、PA、FCP、2hCP低于无营养风险组,差异有统计学意义(P<0.05);多因素Logistic非条件回归分析显示,HbA1c是2型糖尿病周围神经病变患者发生营养风险的危险因素,BMI和ALB是保护因素(P<0.05);有营养风险组住院时间、住院费用均高于无营养风险组,差异有统计学意义(P<0.05);Spearman相关性分析显示营养风险与住院时间、住院费用呈正相关(r=0.147、0.158,P<0.05)。结论 有营养风险组的2型糖尿病周围神经病变患者可能导致不良临床结局。血糖控制差、BMI和ALB偏低的2型糖尿病周围神经病变患者容易出现营养风险,而营养风险可导致患者住院时间、住院费用增加。
Objective To investigate the clinical characteristics of type 2 diabetic peripheral neuropathy patients with nutritional risk.Methods Nutritional risk screening 2002( NRS2002) was used to screen the nutritional risk of 469 patients with type 2 diabetic peripheral neuropathy.According to the score,they were divided into nutritional risk group(122 cases) and non-nutritional risk group(347 cases).The body mass index(BMI),hemoglobin(HB),serum prealbumin(PA),serum albumin(ALB),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),cystatin C(CysC),blood uric acid(UA),glycosylated hemoglobin(HbA1c),fasting C-peptide(FCP),2-hour postprandial C-peptide(2hCP),hospitalization time and hospitalization expenses were compared between the two groups.The risk factors of nutritional risk in patients with type 2 diabetic peripheral neuropathy were analyzed.Results The incidence of nutritional risk in469 patients with type 2 diabetic peripheral neuropathy was 26.01%,the incidence of male was 28.22%,and the incidence of female was 23.68%,the difference was not statistically significant(P>0.05).The age and HbA1c in the nutritional risk group were higher than those in the non-nutritional risk group,and the BMI,TG,UA,HB,ALB,PA,FCP and 2 hCP were lower than those in the non-nutritional risk group( P<0.05).Multivariate Logistic regression analysis showed that HbA1c was a risk factor for nutritional risk in patients with type 2 diabetic peripheral neuropathy,BMI and ALB were protective factors(P <0.05).The hospitalization time and hospitalization expenses of the nutritional risk group were higher than those of the non-nutritional risk group,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that nutritional risk was positively correlated with hospitalization time and hospitalization expenses(r =0.147,0.158,P <0.05).Conclusion Patients with type 2 diabetic peripheral neuropathy in the nutritional risk group may lead to adverse
作者
赖璐华
李玉兰
黄秋菊
刘纳
黄俭美
LAI Lu-hua;LI Yu-lan;HUANG Qiu-ju;LIU Na;HUANG Jian-mei(Department of Endocrinology,Liuzhou People’s Hospital,Liuzhou 545006,Guangxi,China;Department of Nutrition,Liuzhou People’s Hospital,Liuzhou 545006,Guangxi,China)
出处
《医学信息》
2022年第17期120-122,共3页
Journal of Medical Information
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20190101)
广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20190300)。
关键词
糖尿病周围神经病变
2型糖尿病
营养风险
Diabetic peripheral neuropathy
Type 2 diabetes mellitus
Nutritional risk
