摘要
肾细胞癌的主要治疗手段是手术切除,放射治疗主要用于缓解肿瘤转移或抑制局部肿瘤生长。由于肾细胞癌高水平的固有辐射抵抗以及临床研究中实际放疗效果不佳,传统放射治疗在肾细胞癌中应用相对局限。造成肾细胞癌高辐射抵抗的机制尚不完全清楚,可能与缺氧诱导因子-1α、信号转导和转录激活因子1以及DOC-2/DAB2相互作用蛋白有关。随着近些年立体定向消融放射治疗等放疗技术的应用以及质子重离子治疗技术的推广,肾细胞癌的放射治疗有了长足进步。本综述研究放射治疗在肾细胞癌治疗中的新兴作用以及放疗联合免疫治疗的进展。
The main treatment for renal cell carcinoma(RCC) is surgical resection. Radio therapy is mainly used to alleviate tumor metastasis or inhibit local tumor growth. Due to the high level of inherent radio resistance of RCC and the poor efficacy of actual radiotherapy in clinical studies, the application of traditional radiotherapy in RCC is relatively limited. The mechanism of high radio resistance in RCC is not completely clear, though it may be related to hypoxia-inducible factor-1α, signal transducer and activator of transcription1and DOC-2/DAB2 interacting protein. With the application of stereotactic ablative body radiotherapy and the promotion of proton and heavy ion therapy in recent years, the radiotherapy of RCC has made great progress. This article reviewed the emerging role of radiotherapy in the treatment of RCC and the progress of radiotherapy combined with immunotherapy.
作者
杨天赐
丁楠
王伟
Yang Tian-ci;Ding Nan;Wang Wei(The Second School of Clinical Medicine,Lanzhou University,Lanzhou 730030,China;Department of Urology,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Key Laboratory of Space Radiobiology of Gansu Province,Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China)
出处
《兰州大学学报（医学版）》
2022年第6期79-83,共5页
Journal of Lanzhou University（Medical Sciences）
基金
甘肃省卫生健康行业科研计划资助项目(GSWSKY2020-10)
2020年甘肃省高等学校创新基金资助项目(2020B-025)。
关键词
肾细胞癌
放射治疗
辐射抗性
立体定向消融放疗
免疫治疗
带电粒子治疗
重离子
renal cell carcinoma
radio therapy
radio resistance
stereotactic body radiotherapy
immuno therapy
charged particle therapy
heavy ion
