摘要
目的:探讨丹参川芎嗪注射液联合通督调神针法对脑卒中后抑郁(PSD)患者血清神经营养指标和单胺类神经递质的影响。方法:病例选取自2020年3月-2021年9月期间东莞市中医院针灸科收治的98例PSD患者,入选的患者根据随机数字表法分为对照组(丹参川芎嗪注射液治疗,49例)和研究组(通督调神针法联合丹参川芎嗪注射液治疗,49例),两组均治疗6周。观察两组治疗6周后的临床疗效,对比两组中医证候积分、汉密尔顿抑郁量表(HAMD)-17、巴氏指数(BI)、血清神经营养指标[胰岛素样生长因子-1(IGF-1)、脑源性神经营养因子(BDNF)]和单胺类神经递质[去甲肾上腺素(NE)、5-羟色胺(5-HT)和多巴胺(DA)]变化,记录两组不良反应发生率。结果:研究组的临床总有效率为91.84%(45/49),优于对照组的67.35%(33/49),差异有统计学意义(P<0.05)。研究组治疗6周后中医证候总积分、HAMD-17评分低于对照组,BI评分高于对照组(P<0.05)。研究组治疗6周后IGF-1低于对照组,BDNF高于对照组(P<0.05)。研究组治疗6周后NE、5-HT、DA高于对照组(P<0.05)。两组不良反应发生率对比无统计学差异(P>0.05)。结论:通督调神针法联合丹参川芎嗪注射液治疗PSD患者,可促进症状改善,调节神经营养指标,促进单胺类神经递质表达,是一种安全有效的治疗方案。
Objective:To investigate the effects of Tongdu Tiaoshen acupuncture combined with Salvia miltiorrhiza Ligustrazine injection on serum neurotrophic indexes and monoamine neurotransmitters in patients with post-stroke depression(PSD).Methods:98 patients with PSD were selected from the Acupuncture Department of Dongguan Hospital of Traditional Chinese Medicine from March 2020 to September 2021.The selected patients were randomly divided into control group(Danshen ligustrazine injection,49 cases)and study group(Tongdu Tiaoshen acupuncture combined with Danshen ligustrazine injection,49 cases).Both groups were treated for 6 weeks.The clinical effects of the two groups at 6 weeks after treatment were observed,and the changes of TCM symptom score,Hamilton Depression Scale(HAMD)-17,Barbitt index(BI),serum neurotrophic indexes[brain-derived neurotrophic factor(BDNF),insulin-like growth factor-1(IGF-1)]and monoamine neurotransmitters[norepinephrine(NE),5-hydroxytryptamine(5-HT)and dopamine(DA)]were compared between the two groups.The incidence of adverse reactions in the two groups was recorded.Results:The total clinical effective rate of the study group was 91.84%(45/49),which was better than 67.35%(33/49)of the control group,the difference was statistically significant(P<0.05).6 weeks after treatment,the TCM symptom total score and HAMD-17 score of the study group were lower than those of the control group,and the BI score was higher than that of the control group(P<0.05).6 weeks after treatment,IGF-1 of the study group was lower than that of the control group,and BDNF was higher than that of the control group(P<0.05).6 weeks after treatment,NE,5-HT and DA of the study group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tongdu Tiaoshen acupuncture combined with Salvia miltiorrhiza Ligustrazine injection in the treatment of patients with PSD can promote the improvement of symptoms,regulate neurotrophic
作者
梁子威
苏嘉宝
何炎坤
兰俊超
张光正
LIANG Zi-wei;SU Jia-bao;HE Yan-kun;LAN Jun-chao;ZHANG Guang-zheng(Clinical Medical College of Acupuncture and Rehabilitation,Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong,510403,China;Department of Acupuncture,Dongguan Hospital of Traditional ChineseMedicine,Dongguan,Guangdong,523000,China;Department of Rehabilitation Medicine,Dongguan Humen Hospital,Dongguan,Guangdong,523000,China)
出处
《现代生物医学进展》
CAS
2022年第18期3480-3484,共5页
Progress in Modern Biomedicine
基金
广东省教育厅特色创新项目(2016KQNCX027)。
关键词
通督调神针法
丹参川芎嗪注射液
脑卒中后抑郁
神经营养指标
单胺类神经递质
Tongdu tiaosheng acupuncture
Salvia miltiorrhiza ligustrazine injection
Post-stroke depression
Neurotrophic index
Monoamine neurotransmitters
