摘要
目的探讨血清自身抗体检测联合低剂量螺旋CT(LDCT)在肺癌早期筛查中的可行性。方法收集武汉大学人民医院体检中心体检人群12568例体检资料,男7453例、女5115例,筛选出肺癌高危人群1324例纳入本研究,该人群均进行胸部X线检查。随机选取443例患者采用低剂量螺旋CT检测;488例患者采用血清自身抗体进行检测;393例患者采用血清自身抗体联合低剂量螺旋CT检测。均随访一年,比较不同筛查方法对肺结节初筛阳性率及肺癌确诊率,早期肺癌筛查的敏感度及特异性。结果血清自身抗体联合低剂量螺旋CT检测对于发现肺结节的初筛率、肺癌的确诊率及不同直径肺结节的检出率均明显高于低剂量螺旋CT组及血清自身抗体检测组(P<0.001)。血清自身抗体联合低剂量螺旋CT检测的特异性为89.1%,敏感度为88.4%,AUC为0.863。结论血清自身抗体检测联合低剂量螺旋CT可明显提高高危人群早期肺癌筛查的确诊率,为寻找肺癌筛查路径提供理论依据。
Objective To investigate the application value of serum auto-antibody detection combined with low-dose spiral computed tomography(LDCT)in early lung cancer screening.Methods From 12568 medical examination crowd(7453 males and 5115 females),1324 people with high-risk cases of lung cancer in our medical examination center were divided randomly into three groups(LDCT,serum auto-antibody,and serum auto-antibody combined with LDCT groups).All people in this research were screened by chest X-ray.Follow-up was conducted for one year,and the positive screening and diagnosis rates of early lung cancer screening were compared between these groups of high-risk people with lung cancer.Results The positive screening and diagnostic rates of high-risk lung cancer in the serum auto-antibody combined with LDCT group was significantly higher those that in other two groups(P<0.001).The specificity and sensitivity of serum auto-antibody combined with LDCT group were 89.1% and 88.4%,respectively;the area under the ROC curve was 0.863.Conclusion Serum auto-antibody detection combined with low-dose spiral CT can significantly improve the positive screening rate of lung cancer in high-risk populations,providing a strong theoretical support for lung cancer screening pathway.
作者
詹娜
徐威
曾智
董丽玲
ZHAN Na;XU Wei;ZENG Zhi;DONG Liling(Department of Pathology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Medical Examination Center,Renmin Hospital of Wuhan University,Wuhan 430060,China;Medical Examination Center,Union Jiangnan Hospital,Huazhong University of Science and Technology,Wuhan 430200,China)
出处
《肿瘤防治研究》
CAS
CSCD
2022年第9期908-912,共5页
Cancer Research on Prevention and Treatment
基金
中华健康管理博士联盟科研基金(2021HX0019)。
关键词
血清抗体检测
低剂量螺旋CT
早期肺癌
高危人群
Serum autoantibody detection
Low-dose spiral CT
Early stage lung cancer
High-risk population
