摘要
目的观察自拟清热止惊方保留灌肠治疗小儿复杂性热性惊厥的疗效并探讨其作用机制。方法76例患儿按随机数字表法分为观察组与对照组各38例。两组患儿均予综合治疗措施,对照组患儿加用复方苯巴比妥钠静脉注射,观察组在对照组治疗基础上加用自拟清热止惊方保留灌肠。比较两组临床疗效、炎症因子水平、神经因子水平、临床指标及不良反应发生情况。结果观察组临床总有效率89.47%高于对照组的65.79%(P<0.05)。两组治疗后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、神经元特异性烯醇化酶(NSE)、神经肽-Y(NPY)水平均较治疗前下降(均P<0.05),且观察组治疗后CRP、TNF-α、IL-6、NSE、NPY水平均低于对照组(均P<0.05)。观察组出现再次发热时间明显长于对照组,24 h内再次抽搐发生率明显低于对照组(均P<0.05)。对照组出现恶心呕吐2例,四肢麻木1例,不良反应总发生率为7.89%;观察组出现恶心呕吐1例,不良反应总发生率为2.63%。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论自拟清热止惊方保留灌肠治疗复杂性热性惊厥效果与安全性良好,可改善患儿血清炎症因子和神经因子水平,降低患儿再次抽搐次数,缩短再次发热时间。
Objective:To investigate the efficacy and safety of self-made Qingre Zhijing Decoction with retention enema in the treatment of children with complex febrile seizures.Methods:A total of 76 children with complex febrile seizures admitted to our hospital were selected and divided into the observation group and control group according to random number table method,38 cases in each group.Both groups were treated with comprehensive treatment measures.The control group was given diazepam intravenously,and the observation group was given self-made Qingre Zhijing Decoction with retention enema based on the treatment of the control group.The clinical efficacy,levels of inflammatory factors,neurological factors,clinical indicators and adverse reactions were compared between the two groups.Results:The total clinical effective rate in the observation group was 89.47%,which was significantly higher than 65.79%in the control group(P<0.05).After treatment,the levels of CRP,TNF-α,and IL-6 in the observation group were significantly lower than those in the control group,and the levels of NSE and NPY were significantly lower than those in the control group(P<0.05).The time of re-fever in the observation group was significantly longer than that in the control group,and the incidence of re-seizures within 24hours was significantly lower than that in the control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Self-made Qingre Zhijing Decoction has a good effect and safety in the treatment of complex febrile seizures.It can improve the levels of serum inflammatory factors and nerve factors in children,reduce the number of re-seizures,and shorten the time of refever.
作者
董建华
王萍萍
陈永宏
Dong Jianhua;Wang Pingping;Chen Yonghong(Bozhou Hospital of Traditional Chinese Medicine,Anhui,Bozhou 236800,China)
出处
《中国中医急症》
2022年第9期1437-1440,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
安徽省红十字会中医药传承创新发展项目(2021ZYYB10)
2021年亳州市重点研发计划项目(bzzc2021018)。
关键词
小儿复杂性热性惊厥
自拟清热止惊方
保留灌肠
安全性
Complex febrile seizures in children
Self-made Qingre Zhijing Decoction
Retention enema
Safety
