摘要
目的:报道1例很可能的皮质基底节变性患者,以提高临床医生对该病的认识。方法:对1例67岁女性患者的临床表现、体征、脑脊液、影像结果进行分析。结果:患者老年女性,隐袭起病,临床表现为右侧肢体活动不利,右上肢无协同运动,行动迟缓、言语费力。脑脊液总Tau蛋白升高。头部MRI可见双侧大脑半球萎缩,左侧为著,左侧侧脑室扩大。头部18F-FDG PET示双侧大脑半球弥漫性代谢减低,以左侧为著。结论:结合患者临床表现、体征、脑脊液、头部MRI和18F-FDG PET结果,考虑很可能的皮质基底节变性。皮质基底节变性临床表现复杂,容易误诊,临床中应引起重视。
Objective:To report a patient with probable corticobasal degeneration,for increasing the clinician's awareness of the disease.Methods:The clinical manifestations,signs,cerebrospinal fluid and imaging results of a 67-year-old female patient were analyzed.Results:The patient was an elderly female with insidious onset.The clinical manifestations were poor right limb movement,no coordinated movement of the right upper limb,slow movement,labored speech.Elevated total tau protein in cerebrospinal fluid.Head MRI showed bilateral atrophy of the cerebral hemispheres,predominantly on the left side,and the left lateral ventricle was enlarged.18F-FDG PET showed diffuse hypometabolism in both cerebral hemispheres,predominantly on the left side.Conclusion:Combined with the patient's clinical manifestations,signs,cerebrospinal fluid,head MRI and 18F-FDG PET results,the probable corticobasal degeneration was considered.The clinical manifestations of corticobasal degeneration are complex and easy to be misdiagnosed,so attention should be paid to it in clinical practice.
作者
魏妍
王静
Yan WEI;Jing WANG(Department of Neurology,Tsinghua University Yuquan Hospital,Beijing 100040,China)
出处
《阿尔茨海默病及相关病杂志》
2022年第3期209-211,共3页
Chinese Journal of Alzheimer's Disease and Related Disorders
关键词
皮质基底节变性
皮质基底节综合征
磁共振成像
Corticobasal degeneration
Corticobasal syndrome
Magnetic resonance imaging
