摘要
肝脏铁过载是遗传性血色素沉着症和输血性含铁血黄素沉着症的主要组织学特征,如果不进行治疗,过量的铁可导致肝损伤并缓慢发展为肝硬化和肝细胞癌。因此,肝铁浓度的评估对于铁过载的检测和定量分级以及铁螯合治疗的监测是至关重要的。金标准肝活检是有创性的,并且容易出现采样偏差,而MRI技术的非侵入性以及对铁的高敏感性使其成为广为使用的方法。本文将对信号强度比法、T2/R2弛豫法、磁共振波谱成像、T2^(*)/R2^(*)弛豫法、超短回波时间成像技术及定量磁化率成像评估肝铁定量的研究进展进行综述。
Liver iron overload is the main histological feature of hereditary hemochromatosis and transfusion hemosiderinosis,excess iron can result in liver damage,with the slow development of cirrhosis,liver failure,and hepatocellular carcinoma if left untreated.Therefore,assessment of liver iron content is critical for detection,quantitative grading of iron overload and monitoring of iron chelation therapy.Gold standard liver biopsy is invasive and prone to sampling bias,while the non-invasive nature of MRI and its high sensitivity to iron make it a widely used method.The research progress of signal intensity ratio method,T2/R2 relaxation,magnetic resonance spectroscopy,T2^(*)/R2^(*) relaxation,ultrashort echo time imaging technology and quantitative susceptibility mapping to assess liver iron quantification will be reviewed in this article.
作者
王燕
靳向飞
黎斌
陈武标
WANG Yan;JIN Xiangfei;LI Bin;CHEN Wubiao(School of Medical Technology,Guangdong Medical University,Dongguan 523000,China;Department of Radiology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)
出处
《分子影像学杂志》
2022年第5期790-794,共5页
Journal of Molecular Imaging
基金
湛江市科研基金项目(2014A404)。
关键词
磁共振成像
肝脏铁过载
信号强度比
R2弛豫
磁共振波谱成像
R2*弛豫
超短回波时间成像技术
定量磁化率成像
magnetic resonance imaging
liver iron overload
signal intensity ratio method
R2 relaxometry
magnetic resonance spectroscopy
R2*relaxometry
ultrashort echo time imaging technique
quantitative susceptibility mapping
