摘要
目的:观察黄芩汤加减联合针刺辅助西医治疗活动期溃疡性结肠炎湿热蕴结证患者的效果。方法:选取2020年6月至2021年6月该院收治的110例活动期溃疡性结肠炎湿热蕴结证患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各55例。对照组采用美沙拉嗪肠溶片治疗,观察组在对照组基础上采用黄芩汤加减联合针刺治疗,比较两组临床疗效、治疗前后中医证候积分、血清氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.36%(53/55),高于对照组的78.18%(43/55),差异有统计学意义(P<0.05);治疗后,两组腹痛、腹泻、脓血便、里急后重、肛门灼热等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清GSH-Px、SOD水平均高于治疗前,且观察组高于对照组,两组血清MDA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在美沙拉嗪肠溶片治疗基础上采用黄芩汤加减联合针刺治疗活动期溃疡性结肠炎湿热蕴结证患者,可提高治疗总有效率,降低中医证候积分,改善氧化应激指标水平,效果优于单纯美沙拉嗪肠溶片治疗。
Objective:To observe effects of Huangqin decoction combined with acupuncture assisted western medicine in treatment of active ulcerative colitis patients with damp-heat accumulation syndrome.Methods:110 patients with active ulcerative colitis and damp-heat accumulation syndrome in this hospital from June 2020 to June 2021 were selected for the prospective study,and were divided into control group and observation group according to random number table method,55 cases in each group.The control group was treated with Mesalazine entericcoated tablets,while the observation group was treated with Huangqin decoction combined with acupuncture on the basis of that of the control group.The clinical efficacy,the TCM syndrome score,the serum oxidative stress index levels [glutathione peroxidase(GSH-Px),malondialdehyde(MDA),superoxide dismutase(SOD)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 96.36%(53/55),which was higher than the control group of 78.18%(43/55),and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as abdominal pain and burning,diarrhea,pus and blood stool,tenesmus,and anal burning in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).The serum GSH-Px and SOD levels in the two groups were higher than those before the treatment,and those of the observation group were higher than those of the control group;the serum MDA levels in the two groups were lower than those before the treatment,and that of the observation group was lower than that of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of Mesalazine enteric-coated tablets,Huang
作者
杨建军
YANG Jianjun(Department of Traditional Chinese Medicine of Chongren County Maternal and Child Health Hospital,Fuzhou 344200 Jiangxi,China)
出处
《中国民康医学》
2022年第15期88-90,94,共4页
Medical Journal of Chinese People’s Health
关键词
黄芩汤
针刺
活动期溃疡性结肠炎
湿热蕴结证
中医证候积分
氧化应激
不良反应
Huangqin decoction
Acupuncture
Active ulcerative colitis
Damp-heat accumulation syndrome
TCM syndrome score
Oxidative stress
Adverse reaction
