摘要
目的:分析我院2018~2020年中临床上分离的肺炎克雷伯菌的临床分布和耐药性,为临床医师合理使用抗菌药物提供参考。方法:回顾性分析2018~2020年中在住院患者中分离的肺炎克雷伯菌的耐药性,探讨其临床分布及来源。结果:在2018~2020年中,共计分离出肺炎克雷伯菌273株,主要来自痰液,占66.31%,其次是血液占25.75%,胸水占8.06%;ICU病区占比最高,为23.90%,其次是肺病科为19.78%,骨伤科为14.65%。肺炎克雷伯菌对头孢哌酮/舒巴坦、亚胺培南、美罗培南、哌拉西林/他巴唑坦、阿米卡星耐药率较低,对哌拉西林、头孢唑林、头孢呋辛、头孢曲松、磺胺甲恶唑/甲氧苄啶耐药率较高。结论:三年来我院分离的肺炎克雷伯菌耐药趋势变化平稳,应持续加强细菌耐药监测和抗生素使用管理,合理使用抗菌药物。
Objective:To analyze the distribution and antibiotic resistance of Klebsiella pneumoniae in the hospital from 2018 to 2020,so as to provide references for rational use of antibiotics in clinic.Methods:Antibiotic resistance of K.pneumoniae isolated from the inpatients during 2018~2020 was retrospectively analyzed.The clinical distribution and specimen source were also analyzed.Results:A total of 273 K.pneumoniae were isolated from 2018~2020.66.31%of those were from sputum samples,25.75%from blood and 8.06%from hydrothorax.As for the department distribution,23.90%were from ICU,19.78%from pneumology department and 14.65%from orthopedics department.The resistance rates of K.pneumoniae against cefoperazone/sulbactum,imipenem,meropenem,piperacillin/tazobactam,amikacin were comparatively low,while the resistance rates against piperacillin,cefazolin,cefuroxime,ceftriaxone and sulfamethoxazole/trimethoprim were high.Conclusion:The resistance tendency of K.pneumoniae in the hospital remains comparatively stable.Monitoring of bacterial resistance and management of antibiotic use should be continuously strengthened.
作者
张传栋
ZHANG Chuan-dong(Zibo Integrative Hospital,Shandong Zibo 255026)
出处
《医学检验与临床》
2022年第8期39-41,51,共4页
Medical Laboratory Science and Clinics
