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参麦注射液对经皮冠状动脉介入术相关的围手术期心肌梗死的预防作用

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摘要 目的 探讨参麦注射液对冠心病患者经皮冠状动脉介入术相关的围手术期心肌梗死的预防作用.方法 将64例择期手术患者随机分为观察组和对照组,每组32例.术前对照组给予常规药物治疗;观察组在此基础上给予参麦注射液静滴5 d.所有入选病例在入院当天、行经皮冠状动脉介入术(PCI)术前、完成PCI后24 h抽血,取血清测定肌钙蛋白I、基质金属蛋白酶9(MMP-9)、N端脑钠肽前体(NT-ProBNP)、高敏C反应蛋白(hs-CRP)的水平.结果 两组研究对象的年龄、性别、体质量指数(BMI)比较,差异无统计学意义(P>0.05).对照组术后肌钙蛋白I升高水平有显著变化(P<0.05),观察组术后肌钙蛋白I升高水平轻度升高,前后对照无显著变化(P>0.05),两组术后肌钙蛋白I水平有显著变化(P<0.05),观察组患者的hs-CRP、MMP9、NT-proBNP水平均显著低于对照组,差异有统计学意义(P<0.05),观察组围术期心肌梗死发生率3.1%低于对照组9.4%,差异有统计学意义(P<0.05).结论 参麦注射液可通过干预hs-CRP、MMP9介导的围手术期炎症反应降低心肌损伤的发生,对PCI术后心肌具有预防作用. Objective To investigate the protective efect of Shenmai Injection on PCI-related myocardial infarction in patients with coronary artery disease.Methods 64 patients undergoing PCI were randomly divided into study group and control group,32 cases in each group.The control group was given conventional drug treatment,the study group was given Shenmai Injection intravenously for 5 days additionally.Blood was drawn on the day of admision,before PCI,and 24 h after completion of PCI to determine the levels of troponin I(TNI),matrix metalloproteinase 9(MMP9),nterminal pro brain natriuretic peptide(NT-ProBNP),and high sensitivity C-reactive protein(hs-CRP)in ll selected cases.Results There was no statisticlly significant diference in age,sex,and body mass index(BMI)between the two groups(P>0.05).There was a significant change in the postoperative TNI elevation level in the control group(P<0.05),and a mild increase in the postoperative TNI elevation level in the study group,with significant change in the postoperative TNI between two groups(P<0.05).Hs-CRP,MMP9,and NT-proBNP levels in patients in the study group were significantly lower than those in the control group,and the diference with the incidence of perioperative myocardial infarction was lower in the study group at 3.1%than in the control group at 9.4%,and the difference was statisticlly significant(P<0.05).Conclusion Shenmai injection reduces perioperative myocardial infarction by interfering with hs-CRP and MMP9-mediated inflammatory responses,and has a protective fet on patients'myocardium after PCI.
出处 《浙江临床医学》 2022年第8期1179-1181,共3页 Zhejiang Clinical Medical Journal
基金 浙江省医学会临床科研基金项目(2018ZYC-A28) 杭州市卫生科技计划项目(A20200813)。
关键词 参麦注射液 经皮冠脉介入治疗 围手术期心肌梗死 Shenmai injection percutancous coronary intervention PCI related myocardial infarction
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