摘要
糖尿病可通过高血糖引起的微血管病变、周围神经病变等方式严重损害多种器官组织的结构和功能。糖尿病同时也是多种口腔疾病的危险因素。近期研究发现糖尿病可加速牙髓组织的增龄性病理改变,可能与激发的氧化应激反应和炎症免疫反应有关,具有抗炎抗氧化的药物可缓解因糖尿病引起的牙髓组织增龄性改变。因此,本文拟对糖尿病引起的牙髓组织增龄性改变、相关机制及潜在治疗方法作一综述,以期为临床中糖尿病患者牙髓疾病治疗提供理论基础。
Diabetes mellitus can affect the structure and function of cardiovascular and nervous organs by microvascular disorder and peripheral neuropathy caused by hyperglycemia.Diabetes mellitus is also a risk factor for many oral diseases.Recent studies have found that diabetes mellitus can accelerate the aging changes of dental pulp tissue,it may be related to the stimulated oxidative stress response and inflammatory immune response.Drugs with anti-inflammatory and antioxidant properties may relieve aging changes of dental pulp resulting from diabetes mellitus.Therefore,this article aims to review the aging changes of dental pulp tissue caused by diabetes mellitus,related mechanisms and potential treatment methods,in order to provide a theoretical basis for clinical treatment of diabetic mellitus patients with dental pulp disease.
作者
陈小倩
高诗祺
张益
田青鹭
郑黎薇
周雅川
CHEN Xiaoqian;GAO Shiqi;ZHANG Yi;TIAN Qinglu;ZHENG Liwei;ZHOU Yachuan(Department of Pediatric Dentistry,State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology of Sichuan University,Sichuan Province,Chengdu 610041,China;Department of Cariology and Endodontics,State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology of Sichuan University,Sichuan Province,Chengdu 610041,China)
出处
《中国医药导报》
CAS
2022年第27期35-38,46,共5页
China Medical Herald
基金
国家自然科学基金资助项目(81800927)
四川省成都市科技局技术创新研发项目(2019-YF05-00441-SN)
四川大学华西口腔医院探索与研发项目(LCYJ2019-24)。
关键词
糖尿病
牙髓
增龄性病变
氧化应激
炎症反应
Diabetes mellitus
Dental pulp
Aging changes
Oxidative stress
Inflammation
