摘要
SUMO化修饰是一种重要的蛋白质翻译后修饰方式,在细胞周期调控、细胞代谢、基因转录、DNA损伤和修复等众多细胞生物学过程中,对底物蛋白质的表达、定位和活性进行调控。蛋白质SUMO化修饰是动态可逆的过程,去SUMO化修饰由SUMO特异性蛋白酶(SENPs)家族成员所催化。由于受到SUMO化修饰的底物蛋白种类众多、功能多样,SUMO化修饰能够在整体和特定蛋白质修饰层面,参与调控肿瘤的发生发展,并且这种调控机制非常复杂,比如调控细胞周期的进程、DNA损伤和基因组不稳定性、肿瘤代谢与生长、抗肿瘤免疫等。SENPs家族成员是底物蛋白质SUMO化修饰程度的决定者,该研究团队对SENPs家族成员在肿瘤中的作用开展了系列研究,因此该文也将以SENP1和SENP3为例,对SENPs在肿瘤进程中的作用及其作用机制展开介绍。
As an important protein post-translation modification,SUMOylation regulates stability,subcellular localization and activity of its substrates during numerous cellular biological processes,including cell cycle progression,cell metabolism,gene transcription,and DNA damage&repair.SUMOylation is a dynamic and reversible process,with de-SUMOylation mediated by SENPs(SUMO-specific proteases).The regulation of SUMOylation in cancer is complicated,owing to the varieties and multiple functions of its substrates.On global level as well as on individual protein level,SUMOylation regulates cell cycle progression,genome instability and cellular metabolism in tumor cells,and antitumor activity in immune cells,which thereby is greatly involved in tumoreigenesis and tumor progression.By removing SUMOs from specific substrates,SENPs chiefly decides the SUMOylation level of its targets.In this review,based on the studies of our lab for years,the biological roles of SENP1 and SENP3 in cancer will be introduced as well.
作者
蔡蓉
程金科
CAI Rong;CHENG Jinke(Department of Biochemistry&Molecular Cell Biology,Shanghai Jiao Tong University College of Basic Medical Sciences,Shanghai 200025,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2022年第4期531-538,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81872230,82173352)资助的课题。
