摘要
Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a promising herbal medicine for ALD treatment.
基金
supported by the National Science and Technology Major Projects of New Drugs(Nos.2019ZX09301124,2019ZX09201001 and 2019ZX09301-110)
the Project Program of the State Key Laboratory of Natural Medicines(No.SKLNMZZCX201821)
the Natural Science Foundation of Jiangsu Province,China(No.BK20180569)
the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF202008)
the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
and the“Double First-Class”University Project(Nos.CPU2018GY13 and CPU2018PZH03)。
