摘要
目的分析丁苯酞氯化钠联合rt-PA静脉溶栓治疗急性缺血性脑梗死(CIS)的效果。方法从2018年7月-2020年6月烟台海港医院收治的CIS患者中选取68例,按数表法随机分成对照组(使用rt-PA溶栓)和试验组(丁苯酞氯化钠联合rt-PA溶栓),均为34例。观察治疗效果,比较炎症因子水平、神经功能和生活质量。结果①试验组治疗后的总有效率比对照组要高(94.12%vs 76.47%),差异有统计学意义(P<0.05)。②患者治疗前的IL-6、CRP水平相近(P>0.05),治疗后检测结果降低,而且试验组低于对照组(P<0.05)。③治疗后、随访6个月,患者NIHSS评分降低、ADL评分增高,试验组评分结果较之对照组更优(P<0.05)。结论丁苯酞氯化钠联合rt-PA静脉溶栓治疗CIS疗效确切,能改善炎症因子水平,促进神经功能修复,改善患者的生活质量,值得推广应用。
Objective To analyze effect of butylphthalide sodium chloride combined with rt-PA intravenous thrombolysis in treatment of cerebral ischemic stroke(CIS).Methods The paper chose 68 cases CIS patients admitted to Yantai Haigang Hospital from July 2018 to June 2020,and divided them into control group(with rt-PA thrombolysis)and test group(with butylphthalide sodium chloride combined with rt-PA thrombolysis)randomLy according to number table method,with 34 cases in each group.Curative effect was observed and levels of inflammatory factors,neurological function and life quality was compared.Results①Total effective rate of experimental group was higher than control group(94.12%vs76.47%),difference was statistically significant(P<0.05).②Levels of IL-6 and CRP were similar before treatment,(P>0.05),test results decreased after treatment,levels of IL-6 and CRP in test group were lower than control group(P<0.05).③After treatment and follow-up for 6 months,NIHSS scores decreased and ADL scores increased,scores of experimental group were better than control group,(P<0.05).Conclusion Butylphthalide sodium chloride combined with rt-PA intravenous thrombolysis can achieve significant effect in treatment of CIS,can improve level of inflammatory factors,promote repair of neural function,and improve life quality of patients,which is worthy of promotion and application.
作者
曲艺
QU Yi(Yantai Haigang Hospital,Yantai,Shandong,264000)
出处
《智慧健康》
2022年第21期53-56,共4页
Smart Healthcare
