摘要
目的探讨血清乳酸和胆碱酯酶活性对脓毒症患者病情严重程度和预后的评估价值.方法收集2020年9月-2021年9月在中山大学附属东华医院(东莞东华医院)进行治疗的脓毒症患者,共150例.根据患者病情的严重程度将其分为脓毒症组(n=104)和脓毒症休克组(n=46);根据患者的存活情况将其分为存活组(n=112)和死亡组(n=38).收集所有患者的一般资料、乳酸和血清胆碱酯酶活性、APACHEII评分和SOFA评分,并收集患者治疗28天后的预后情况.结果脓毒症组患者的胆碱酯酶活性显著高于脓毒症休克组患者;而血清乳酸、APACHEII和SOFA评分则显著小于脓毒症休克组患者;存活组患者的胆碱酯酶活性显著高于死亡组患者;而血清乳酸、APACHEII和SOFA评分则显著小于死亡组患者;胆碱酯酶是脓毒症患者病情严重程度和预后的保护因素,而乳酸、APACHEII评分则是脓毒症患者严重程度和预后的独立危险因素;胆碱酯酶、乳酸、胆碱酯酶联合乳酸、APACHEII评分均对脓毒症患者病情严重程度和预后具有预测价值.结论血清乳酸和乙酰胆碱酶活性对脓毒症患者病情和预后有良好的评估价值,可以协助临床医生对脓毒症患者的病情和预后作出快速且准确的判断.
Ob jective To investigate the value of serum lactate and cholinesterase activities in evaluating the severity and prognosis of patients with sepsis.Methods A total of 150 patients with sepsis treated in our hospital from September 2020 to September 2021 were collected.Patients were divided into sepsis group(n=104)and septic shock group(n=46)according to the severity of their disease.Patients were divided into survival group(n=112)and death group(n=38)according to their survival.General information,lactic acid and serum cholinesterase activities,APACHEIl score and SOFA score were collected for all patients,and the outcomes of patients after 28 days of treatment were cllected.Results The cholinesterase activity of patients with sepsis was significantly higher than that of patients with septic shock.The scores of serum lactic acid,APACHEIl and SOFA were significantly lower than those in septic shock group.The cholinesterase activity in survival group was significantly higher than that in septic shock group.Serum lactic acid,APACHEIl and SOFA scores were significantly lower than those in death group.Cholinesterase was a protective factor for severity and prognosis of sepsis patients,while lactic acid,APACHEIl scores were independent risk factors for severity and prognosis of sepsis patients.The scores of cholinesterase,lactic acid,cholinesterase combined with lactic acid,APACHEII had predictive value for the severity and prognosis of sepsis patients.Conc lus ion Serum lactic acid and acetylcholinase activities have good evaluation value for the condition and prognosis of patients with sepsis,which can help clinicians to make arapid and accurae judgment of the condition and prognosis of patients with sepsis.
作者
陈丹
钟坚
吴燕妮
Chen Dan;Zhong Jian;Wu Yanni(Department of Emergency Medicine,tung wah hospital(Dongguan tung wah hospital),Sun Yat-sen University,Dongguan,Guangdong 523110,China)
出处
《首都食品与医药》
2022年第17期37-40,共4页
Capital Food Medicine
关键词
脓毒症
乙酰胆碱
乳酸
休克
预后
Sepsis
Acetylcholine
Lactic acid
Shock
The prognosis
