摘要
目的 探讨3~19岁高原世居藏族儿童青少年血常规指标水平及其变化趋势,为建立该人群血常规参考值范围提供依据。方法 采取整群随机抽样方法,以西藏日喀则地区1 568名3~19岁高原世居藏族儿童青少年为研究对象,进行血常规检测,比较各年龄组、不同性别人群血常规指标水平并分析其随年龄变化趋势。结果 红细胞计数(RBC)、血红蛋白质量浓度(HGB)、红细胞压积(HCT)、平均红细胞体积(MCV)、红细胞平均血红蛋白含量(MCH)、白细胞计数(WBC)、中性粒细胞计数(NEU)、中性粒细胞计数百分比(NEU%)、淋巴细胞数(LYM)、淋巴细胞数百分比(LYM%)、单核细胞计数比例(MON%)、嗜酸性粒细胞计数比例(EOS%)、嗜碱性粒细胞计数比例(BAS%)、血小板计数(PLT)在3~5,6~12,13~15,16~19岁4个年龄段间差异均有统计学意义(F/H值分别为60.22,179.41,249.45,115.03,74.90,14.34,33.46,78.90,49.20,97.29,24.45,24.28,42.65,20.10,P值均<0.05),其中RBC、HGB、HCT、MCH红细胞指标在藏族男生中随年龄呈现上升趋势(F值分别为148.77,493.04,623.14,249.92,P值均<0.05),在女生中无显著变化趋势(F值分别为1.37,0.15,2.94,0.11,P值均>0.05)。HCT在3~5,6~12,13~15,16~19岁年龄段的男女生间[(41.33±2.31)%,(41.98±2.40)%;(43.28±2.60)%,(43.75±2.36)%;(46.20±3.11)%,(44.83±2.67)%;(51.10±4.15)%,(43.61±4.70)%]差异均有统计学意义(t值分别为-2.10,-2.88,3.50,10.82,P值均<0.05)。WBC、NEU、NEU%、LYM、LYM%、单核细胞计数(MON)、MON%等指标在男女中随年龄具有相同的变化趋势(P值均<0.05)。从12~13岁开始,RBC、HGB、HCT在高原世居藏族男性与女性青少年中呈现相反的变化趋势并逐渐拉开差距。结论 红细胞指标在不同年龄、性别的高原世居藏族儿童青少年中变化趋势差异显著,在制定血常规参考值范围时应考虑地域民族、年龄、性别等因素影响。
Objective To investigate routine blood test results and secular changes among Tibetan children and adolescents aged from 3 to 19 in the plateau,and to provide the basis for reference range of routine blood test for this population.Methods A total of 1 568 Tibetan children and adolescents aged from 3 to 19 living in Shigatse,Tibet were selected by cluster random sampling method.Routine blood test results and its secular trends were compared by age and gender.Results Significantly differences were found in red blood cell(RBC),hemoglobin(HGB),hematocrit(HCT),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),white blood cell(WBC),neutrophil(NEU),neutrophil percentage(NEU%),lymphocyte(LYM),lymphocyte percentage(LYM%),monocyte percentage(MON%),eosinophil percentage(EOS%),basophil percentage(BAS%) and platelet(PLT) among the four age groups of 3-5,6-12,13-15,and 16-19 years(F/H=60.22,179.41,249.45,115.03,74.90,14.33,33.46,78.90,49.20,97.29,24.45,24.28,42.65,20.10,P0.05).HCT showed significant sex differences among the four age groups of 3-5 years,6-12 years,13-15 years,and 16-19 years [(41.33±2.31)% vs(41.98±2.40)%;(43.28±2.60)% vs(43.75±2.36)%;(46.20±3.11)% vs(44.83±2.67)%;(51.10±4.15)% vs(43.61±4.70)%,t=-2.10,-2.88,3.50,10.82,P<0.05].WBC,NEU,NEU%,LYM,LYM%,monocyte(MON),and MON% increased significantly with age in both boys and girls(P<0.05).From the age of 12 to 13,RBC,HGB and HCT in Tibetan male and female adolescents showed an opposite trend and widened gradually.Conclusion Red blood cell index shows significantly different trends among Tibetan adolescents and children of different ages and genders.Regional nationality,age,gender,and other factors should be considered when developing the reference value range of blood routine index.
作者
谢慎威
许珂
董明
施俊屹
曹玖见
董华平
吴玉
李鹏
谢佳新
XIE Shenwei;XU Ke;DONG Ming;SHI Ju-nyi;CAO Jiujian;DONG Huaping;WU Yu;LI Peng;XIE Jiaxin(Department of Infectious Disease,the 953rd Hospital of PLA,Shigatse 857000,Tibet Autonomous Region,China;不详)
出处
《中国学校卫生》
CAS
北大核心
2022年第8期1235-1240,共6页
Chinese Journal of School Health
基金
国家自然科学基金项目(81571842)。
关键词
血液
健康调查
方差分析
儿童
青少年
少数民族
Blood
Health surveys
Analysis of variance
Child
Adolescent
Minority groups
