摘要
目的 研究内蒙古6~17岁儿童青少年高尿酸血症(hyperuricemia,HUA)的患病情况和高三酰甘油腰围(hypotriglyceridemic-waist,HTW)表型的检出情况,并探讨两者的关系,为内蒙古儿童青少年高尿酸血症的防治提供依据。方法采用多阶段分层随机抽样的方法选择内蒙古8个旗县(区)的小学、初中和高中2 175名学生进行问卷调查、体格检查和实验室检测。采用二元Logistic回归分析HTW表型和HUA的相关性。结果 研究对象HTW表型检出率为2.1%,男生检出率(2.5%)高于女生(1.6%)(χ^(2)=14.50,P<0.05)。血尿酸(serum uric acid,SUA)平均水平为308.00(259.00,371.00)mmol/L,性别间差异有统计学意义(Z=-9.87,P<0.05),HUA患病率为21.1%。HTW表型的HUA患病率(44.4%)高于其他表型,其次为高腰围(enlarged waist,EW)表型(36.2%)。校正其他因素后,EW表型(OR=1.76,95%CI=1.26~2.47)和HTW表型(OR=2.25,95%CI=1.12~4.52)与HUA发病均呈正相关(P值均<0.05)。结论 内蒙古6~17岁儿童青少年的HUA患病率较高,HTW表型与高尿酸血症呈正相关。在高尿酸血症的预防中,应加强对具有HTW表型儿童青少年的关注。
Objective To investigate the prevalence and association of hyperuricemia(HUA) and hypertriglyceridemic-Waist(HTW) phenotype in children and adolescents aged 6-17 years in Inner Mongolia,providing a basis for the prevention and treatment of hyperuricemia in adolescents in Inner Mongolia.Methods A total of 2 175 students of primary,junior high,and senior high school students from eight counties(districts) in Inner Mongolia were chosen and received a questionnaire survey,physical examination,and laboratory test by used a multi-stage stratified random sampling approach.The association between the HTW phenotype and HUA was analyzed using binary Logistic regression.Results The prevalence of the HTW phenotype was 2.1%,with boys(2.5%) higher than that of girls(1.6%)(χ^(2)=14.50,P<0.05).The average SUA level of the participants was 308.00(259.00,371.00) mmol/L,with a statistically significant sex difference(Z=-9.87,P<0.05).The prevalence of HUA was 21.1%.The frequency of HUA in the HTW phenotype(44.4%) was higher than in other phenotypes,followed by enlarged waist(EW) phenotype.After controlling for associated variables,the EW phenotypes(OR=1.76,95%CI=1.26-2.47) and HTW phenotypes(OR=2.25,95%CI=1.12-4.52) were associated with higher risk for HUA(P<0.05).Conclusion In Inner Mongolia,the prevalence of HUA in children and adolescents aged 6-17 years is high,and there shows a positive association between the HTW phenotype and hyperuricemia.For the prevention of hyperuricemia,more attention should be paid to children and adolescents with HTW phenotype.
作者
曹宁
李乐慧
张楠
牛丽薇
吕海明
张星光
CAO Ning;LI Lehui;ZHANG Nan;NIU Liwei;LYU Haiming;ZHANG Xingguang(School of Public Health,Inner Mongolia Medical University,Hohhot 010110,China;不详)
出处
《中国学校卫生》
CAS
北大核心
2022年第7期1075-1078,共4页
Chinese Journal of School Health
基金
内蒙古自治区自然科学基金项目(2020MS08048)
内蒙古自治区高等学校科学研究项目(NJZY22617)。
关键词
高尿酸血症
患病率
回归分析
儿童
青少年
Hyperuricemia
Prevalence
Regression analysis
Child
Adolescent
