摘要
蛋白质超分子聚合物在生命体的组成和代谢中发挥着重要的作用.天然蛋白质超分子聚合物高级功能的行使离不开其组装策略和组装结构的独特优势.近年来,以“自下而上”的方式构建丰富多样功能性的蛋白质超分子聚合物已成为人们所关注的热点之一.本文介绍了金属配位作用、主客体相互作用、多重氢键相互作用、亲疏水相互作用、π-π相互作用、受体识别相互作用及静电相互作用等多种构筑蛋白质超分子聚合物的经典策略,并分析讨论了其各自特点.基于蛋白质超分子聚合物的独特结构与功能优势,综述了其在生物催化、生物载药与释放、构建人工光捕获系统、生物传感及其他多种功能性材料领域的应用,阐明了蛋白质超分子材料的巨大应用潜能和重要意义,并对其制备与应用仍面临的挑战和其未来发展方向进行了展望.
Protein polymers play an important role in biological composition and life activities.Formed through multiple supramolecular interactions,assembly structures of natural supramolecular protein polymers that were preserved in natural selection could satisfy the various advanced life events.To better explore the mysteries of life,in recent years,the construction of protein supramolecular polymers with various and diverse functionalities in a“bottom-up”approach has become one of the hotspots of interest.Flexible construction strategies could be considered as one of the decisive factors for the successful construction of protein supramolecular polymers.In this paper,we introduce some of the most classical constructing strategies of protein supramolecular polymers based on metal coordination,host-guest interactions,multiple hydrogen bond interactions,hydrophobic interactions,π-πinteractions and receptor recognition interactions,and their respective characteristics were analyzed and discussed.Due to their good biocompatibility and well-defined structure at the nanoscale,protein polymers act as advanced materials in the biological related fields.Based on the unique structural and functional advantages of protein supramolecular polymers,their applications in biocatalysis,medical diagnosis and treatment,biomimetic light harvesting systems,biosensing and other functional materials were introduced in this paper.The significance of the construction of protein supramolecules and its application potential were also clarified.Finally,the challenges of the preparation and application of protein supramolecular polymers as well as its tendency of future development are prospected.
作者
李逸佳
田瑞桢
徐家云
侯春喜
罗全
刘俊秋
Yi-jia Li;Rui-zhen Tian;Jia-yun Xu;Chun-xi Hou;Quan Luo;Jun-qiu Liu(State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012;College of Material,Chemistry and Chemical Engineering,Hangzhou Normal University,Hangzhou 311121)
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2022年第10期1217-1238,共22页
Acta Polymerica Sinica
基金
国家重点科研发展计划(项目号2020YFA0908500,2018YFA0901600)
国家自然科学基金(基金号22161142015,22001054,22075065)资助项目.
关键词
蛋白质组装
超分子作用
蛋白质相互作用
纳米材料
生物功能化
Protein self-assembly
Supramolecular interfaces
Protein-protein interactions
Nano materials
Biofunctionalization
