摘要
目的探讨视神经脊髓炎谱系疾病(NMOSD)患者全身免疫炎症指数(SII)与NMOSD疾病活动的相关性。方法回顾性收集2015年1月至2020年12月作者医院收治的NMOSD患者55例,其中男18例,女37例。另收集年龄、性别构成匹配的健康体检者100名作为对照组。比较NMOSD患者发作期(首发临床症状或临床复发1周内,n=55)、恢复期(随访6个月时,n=44)及对照组间SII以及白细胞计数、中性粒细胞绝对值、淋巴细胞绝对值、血小板计数的差异;比较NMOSD患者水通道蛋白4抗体(AQP4-Ab)阳性组和阴性组SII及白细胞计数、中性粒细胞绝对值、淋巴细胞绝对值、血小板计数的差异;采用受试者工作特征(ROC)曲线分析SII在预测NMOSD疾病活动性中的价值。结果NMOSD患者发作期白细胞计数、中性粒细胞绝对值及SII显著高于恢复期和对照组(均P<0.01),淋巴细胞绝对值显著低于恢复期(P<0.05)和对照组(P<0.01)。而NMOSD患者恢复期白细胞计数、中性粒细胞绝对值、淋巴细胞绝对值及SII与对照组比较无统计学差异(P>0.05)。NMOSD患者AQP4-Ab阳性和阴性组发作期白细胞计数、中性粒细胞绝对值、淋巴细胞绝对值、血小板计数和SII比较无统计学差异(P>0.05)。SII值判断NMOSD患者是否处于发作期的ROC的AUC为0.682(P=0.002,95%CI:0.577~0.787)。结论NMOSD患者临床发作时白细胞计数、中性粒细胞绝对值及SII明显升高,SII升高可能是NMOSD发作期疾病活动的外周炎性指标之一。
Objective To explore the correlation between the systemic immune inflammation index(SII)and disease activity in patients with neuromyelitis optica spectrum disorders(NMOSD).Methods A retrospective study of 55 NMOSD patients admitted to our hospital from January 2015 to December 2020 was performed,including 18 males and 37 females.One hundred age and sex matched healthy subjects were enrolled as the control group.We compared the differences in SII,white blood cells(WBC),neutrophils,lymphocytes and platelets count between NMOSD patients in attack stage(within 1 week of the first clinical symptom or clinical recurrence,n=55),recovery stage(at 6 months follow-up,n=44)and control group.Furthermore,the differences in SII,WBC,neutrophils,lymphocytes and platelets count between aquaporin-4 antibody(APQ4-Ab)positive and APQ4-Ab negative NMOSD patients were also compared.The receiver operating characteristic(ROC)curve was used to analyze the value of SII in predicting disease activity of NMOSD.Results Patients in attack stage showed significantly higher WBC count,absolute neutrophil count,and SII(all P<0.01),and lower absolute lymphocyte count than those in patients in recovery stage and the controls.There were no significant differences between NMOSD patients in recovery stage and control group in WBC count,absolute neutrophil and lymphocyte count,and SII(P>0.05).There were no statistically significant differences between APQ4-Ab positive and APQ4-Ab negative patients with NMOSD in attack stage in the WBC count,absolute neutrophil count,absolute lymphocyte count and SII(P>0.05).The AUC of the ROC for SII to determine whether the NMOSD patients were in the attack stage was 0.682(P=0.002,95%CI:0.577-0.787).Conclusions Patients with NMOSD have significantly higher WBC counts,absolute neutrophil counts and SII in attack stage.Increasing SIIs could be an inflammatory marker of NMOSD in attack stage.
作者
孙庆利
孙阿萍
傅瑜
樊东升
SUN Qingli;SUN APing;FU Yu;FAN Dongsheng(Department of Neurology,Perking University Third Hospital,Beijing 100191,China)
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2022年第5期362-365,共4页
Chinese Journal of Neuroimmunology and Neurology
关键词
视神经脊髓炎谱系疾病
全身免疫炎症指数
相关性
neuromyelitis optica spectrum disorders
systemic immune-inflammation index
correlation
