摘要
目的:探讨经鼻高流量湿化氧疗(HFNC)治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭的效果。方法:选取94例AECOPD合并Ⅱ型呼吸衰竭患者,按随机数字表法分为两组,每组各47例。对照组行无创正压通气(NIPPV)治疗,观察组行HFNC治疗,比较治疗后两组通气效果。结果:治疗后,观察组血氧分压(PaO_(2))较对照组高,二氧化碳分压(PaCO_(2))较对照组低,观察组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)及FEV_(1)/FVC较对照组高,呼吸支持时间、呼吸困难缓解时间及住院时间较对照组短(P<0.05);观察组并发症发生率比对照组低(P<0.05)。结论:HFNC治疗可减轻AECOPD伴Ⅱ型呼吸衰竭患者肺损伤,加快动脉血气复常,缩短呼吸支持时间,减少并发症发生。
Objective:To investigate the effect of high-flow nasal cannula(HFNC)humidified oxygen therapy in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with type Ⅱ respiratory failure.Methods:A total of 94 AECOPD patients complicated with type Ⅱ respiratory failure were randomized into two groups,each with 47 cases.The control group received non-invasive positive pressure ventilation(NIPPV)treatment,while the observation group received HFNC treatment.Then the ventilation effects were compared between both groups.Results:After treatment,PaO_(2) in the observation group was higher than that in the control group,and PaCO_(2) was lower than that in the control group(P<0.05);forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),and FEV1/FVC was higher than that in the control group;the respiratory support time,time for relief of dyspnea and hospital duration was shorter than that of the control group(P<0.05);and the complication rate of the observation group was lower than that of the control group(P<0.05).Conclusion:For AECOPD patients complicated with type Ⅱ respiratory failure,HFNC therapy can reduce lung injury,accelerate the normalization of arterial blood gas,shorten the time of respiratory support,and reduce the occurrence of complications.
作者
宋运远
李德烈
谭运宝
王小龙
刘民军
付鸿雁
SONG Yunyuan;LI Delie;TAN Yunbao;WANG Xiaolong;LIU Minjun;FU Hongyan(Guangdong Provincial People′s Hospital Ganzhou Hospital/Ganzhou Municipal Hospital,Ganzhou 341000,China)
出处
《华夏医学》
CAS
2022年第4期81-85,共5页
Acta Medicinae Sinica
关键词
慢性阻塞性肺疾病
Ⅱ型呼吸衰竭
经鼻高流量湿化氧疗
无创正压通气
chronic obstructive pulmonary disease(COPD)
typeⅡrespiratory failure
high-flow nasal cannula(HFNC)humidified oxygen therapy
non-invasive positive pressure ventilation(NIPPV)
