摘要
目的探讨血必净注射液治疗脓毒症急性肾损伤疗效以及炎性因子、循环、呼吸功能影响性。方法选取2019年1月1日—2020年12月30日来医院就诊的脓毒症急性肾损伤共110例患者,按治疗方案不同分成两组,对照组(55例)连续肾替代治疗,观察组(55例)辅以血必净注射液,均治疗1周。观察治疗前、治疗1周后在住院时间、炎症因子、呼吸和循环等指标变化并比较,并总结疗效和28 d死亡率。结果(1)两组治疗1周后降钙素原、肿瘤坏死因子-α、白细胞介素-6、C反应蛋白含量和治疗前比较均显著下降(P<0.05),且观察组显著优于对照组,差异有统计学意义(P<0.05)。(2)两组治疗1周后氧分压、氧合指数、平均动脉压、尿量和治疗前比较均不同程度上升(P<0.05),肺血管外肺水指数、肌酐、心率和治疗前比较均显著下降(P<0.05),且观察组以上指标改善程度均显著优于对照组(P<0.05)。(3)对照组痊愈率12.73%(7/55)、总有效率47.28%(26/55),观察组痊愈率21.82%(12/55)、总有效率58.18%(32/55),观察组显著高于对照组,差异有统计学意义(χ^(2)=8.115、P<0.000)。(4)两组治疗1周后急性生理和慢性健康状况评分Ⅱ、全身性感染相关性器官功能衰竭评分较治疗前均显著下降(P<0.05),且观察组下降水平显著优于对照组(均P<0.05)。(5)观察组机械通气时间、ICU住院时间、住院费用显著少于对照组,28 d死亡率为34.55%,显著低于对照组的43.64%,差异有统计学意义(P<0.05)。结论血必净注射液治疗脓毒症急性肾损伤疗效可靠,能抑制炎性因子,改善循环、呼吸功能,缩短ICU住院时间,降低费用,提高疗效,降低28 d死亡率。
Objective To investigate the efficacy of Xuebijing Injection(血必净注射液)in the treatment of septic acute kidney injury and the influence on inflammatory factors,circulatory and respiratory functions.Methods A total of 110 patients with acute kidney injury due to sepsis from January 1,2019 to December 30,2020 were selected and divided into two groups according to different treatment schemes.The control group(55 cases)was treated with continuous renal replacement therapy,and the observation group(55 cases)was treated with Xuebijing Injection for one week.The changes of hospitalization time,inflammatory factors,respiratory and circulatory indexes before and after treatment were observed and compared,and the curative effect and 28-day mortality were summarized.Results(1)The contents of procalcitonin,tumor necrosis factor-α,interleukin-6 and C-reactive protein in the two groups were significantly decreased after 1 week of treatment(P<0.05),and those of the observation group were significantly better than those of the control group,and the difference was statistically significant(P<0.05).(2)After one week of treatment,the oxygen partial pressure,oxygenation index,mean arterial pressure and urine volume of the two groups were increased in varying degrees compared with those before treatment(P<0.05).The extravascular lung water index,creatinine and heart rate were significantly decreased compared with those before treatment(P<0.05),and the improvement degree of the above indexes in the observation group was significantly better than that in the control group(P<0.05).(3)The cure rate and total effective rate of the control group were 12.73%(7/55)and 47.28%(26/55),respectively.The cure rate and total effective rate of the observation group were 21.82%(12/55)and 58.18%(32/55),respectively.The difference between the two groups was statistically significant(χ^(2)=8.115,P<0.000).(4)After one week of treatment,the scores of acute physiology and chronic health II and systemic infection related organ failure in the two
作者
林传钦
翟秀丽
张良福
陈胜
LIN Chuanqin;ZHAI Xiuli;ZHANG Liangfu;CHEN Sheng(Sanya Central Hospital,The Third People’s Hospital of Hainan Province,Sanya 572000,Hainan,China;Sanya Leprosy Control Center,Sanya 572000,Hainan,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第7期55-58,共4页
Chinese Archives of Traditional Chinese Medicine
基金
中华医学会临床医学科研专项基金(197305963276)
海南省卫生计生行业科研项目(19A200072)。
关键词
血必净注射液
脓毒症
急性肾损伤
炎性因子
循环、呼吸功能
脏器评分
疗效
Xuebijing Injection(血必净注射液)
sepsis
acute kidney injury
inflammatory factors
circulatory and respiratory functions
organ score
curative effect
