摘要
目的:分析不同剂量叶酸治疗肥胖型多囊卵巢综合征临床疗效及对患者炎性因子的影响。方法:选取2019年12月-2020年12月本院诊治的肥胖型多囊卵巢综合征患者150例,根据叶酸治疗剂量不同分为低剂量组(1mg/d)及高剂量组(5mg/d)各75例,比较两组患者治疗前后炎性因子、糖脂代谢指标及不良反应。结果:治疗后,两组超敏C反应蛋白、白介素-18、肿瘤坏死因子-α水平均降低(P<0.05),但两组间无差异(P>0.05);两组胰岛素抵抗指数均降低,高剂量组空腹胰岛素水平(9.15±4.11 mIU/L)低于低剂量组(12.37±4.79 mIU/L),高剂量组总胆固醇(3.12±1.05 mmol/L)、低密度脂蛋白(2.23±0.71 mmol/L)水平较治疗前下降且低于低剂量组(4.23±1.05 mmol/L、2.96±0.90 mmol/L)(均P<0.05);两组治疗后均未出现明显不良反应。结论:对肥胖型PCOS患者予以5mg叶酸治疗,可减轻患者亚临床炎症及胰岛素抵抗,治疗效果更佳且未增加不良反应。
Objective: To analyze the clinical efficacy of different doses of folic acid for treating obese patients with polycystic ovary syndrome(PCOS), and to study its influence on their levels of inflammatory factors. Methods: 150 obese patients with PCOS were selected and divided into group A(75 patients were given 1 mg/d folic acid) and group B(patients were given 5 mg/d folic acid) according to the different dose of folic acid used from December 2019 to December 2020. The levels of inflammatory factors and glucose and lipid metabolism indicators, and the rate of adverse reactions of the patients before and after treatment were compared between the two groups. Results: After treatment, the levels of hypersensitive C-reactive protein, interleukin-18, and tumor necrosis factor-α of the patients in the two groups had decreased significantly(P<0.05), but which of the patients had no significant difference between the two groups(P>0.05). The values of insulin resistance indexes of the patients after treatment had decreased significantly, and the fasting insulin level of the patients in group B(9.15±4.11 mIU/L) was significantly lower than that(12.37±4.79 mIU/L) of the patients in group A. The levels of total cholesterol and low density lipoprotein of the patients in the two groups after treatment had decreased significantly, and which(3.12±1.05 mmol/L and 2.23±0.71 mmol/L) of the patients in group B were significantly lower than those(4.23±1.05 mmol/L and 2.96±0.90 mmol/L) of the patients in group A(P<0.05). There was no any patient with obvious adverse reactions in both groups after treatment. Conclusion: 5 mg/d folic acid for treating the obese patients with PCOS can reduce their subclinical inflammation and insulin resistance, and which has better therapeutic effect without increase of the side effects.
作者
王丽先
尹倩倩
王彩研
金洁琼
WANG Lixian;YIN Qianqian;WANG Caiyan;JIN Jieqiong(Jiaozhou Central Hospital,Qingdao,Shandong Province,266300)
出处
《中国计划生育学杂志》
2022年第8期1730-1733,共4页
Chinese Journal of Family Planning
关键词
肥胖型多囊卵巢综合征
叶酸
不同剂量
炎症
糖脂代谢
胰岛素抵抗
疗效
Obese and polycystic ovary syndrome
Folic acid
Different doses
Inflammatory
Glucolipid metabolism
Insulin resistance
Therapeutic effect
