摘要
目的 分析琼南地区2016—2018年新生儿高促甲状腺素(thyroid stimulating hormone,TSH)血症流行病学特征及对治疗后婴儿生长发育的影响。方法 回顾性分析2016年1月1日—2018年12月31日琼南地区海南省三亚中心医院/海南省第三人民医院新生儿科出生的新生儿中高TSH血症患儿的临床特征,描述其流行病学特征、人群分布、地区分布及相关影响因素。结果 2016年1月1日—2018年12月31日琼南地区新生儿76 094例,确诊为高促甲状腺素血症新生儿2 461例,发病率每年从2.75%上升至3.65%。高TSH血症患儿的孕母分娩方式,因各种原因剖宫产者1 658例(占67.4%),有宫内窒息史1 892例(76.9%),数据显示以剖宫产、窒息史多见,阴道分娩803例(32.6%)。结论通过琼南地区三年的高TSH血症患儿发病调查,发现高TSH血症患儿以三亚地区多见、家庭经济困难、第一胎者、男孩多见,早产儿、有窒息等高危儿多见,与民族无明显相关性,确诊后全部病例均给予左甲状腺素片(levothyroxine tablets,L-T_(4))替代治疗,无1例出现甲状腺功能亢进症,观察临床生长发育情况良好,智力正常,定时随访,及时调整用药,无过度治疗情况发生。
Objective To analyze the epidemiological characteristics of neonatal thyroid stimulating hormone(TSH) in Qiongnan area from 2016 to 2018 and the effect of treatment on the growth and development of infants. Methods A retrospective analysis was conducted on the clinical characteristics of neonatal children with high TSH in Hainan Sanya Central Hospital/The Third People’s Hospital of Hainan Province from January 1, 2016 to December 31, 2018, and the epidemiological characteristics, population distribution, regional distribution and related influencing factors were described. Results From January 1, 2016 to December 31, 2018, 76 094 cases of newborn babies in Qiongnan area were diagnosed as 2 461 cases of hyperthyroxemia, the incidence rate increased from 2.75% to 3.65% every year. Among the delivery methods of pregnant mothers of children with high TSH hyperemia,1 658 cases(67.4%) had cesarean section due to various reasons, and 1 892 cases(76.9%) had a history of intrauterine asphyxia. The data showed that the history of cesarean section and asphyxia were more common, and 803 cases(32.6%) were vaginal delivery. Conclusion According to the investigation on the incidence of children with high TSH in Qiongnan area for three years, it was found that children with high TSH were more common in Sanya area, family economic difficulties, first child, boys, premature infants, asphyxia and other highrisk infants, and there was no significant correlation with nationality.After diagnosis, all cases were given levothyroxine tablets(L-T_(4))replacement therapy. No hyperthyroidism occurred in 1 case. The clinical growth and development were observed to be good, and the intelligence was normal. Regular follow-up and timely adjustment of medication were performed, and no overtreatment occurred.
作者
张雪梅
谢邦贵
陈小冰
严燕燕
陈求凝
ZHANG Xuemei;XIE Banggui;CHEN Xiaobing;YAN Yanyan;CHEN Qiuning(Department of Neonatology,Sanya Central Hospital/The Third People’s Hospital of Hainan Province,Sanya Hainan 572000,China)
出处
《中国卫生标准管理》
2022年第15期54-57,共4页
China Health Standard Management
基金
海南省三亚市医疗卫生科技创新项目(2018YW26)
海南省卫生计生行业科研项目(18A200080)。
