摘要
[目的]评价基于智能手机监测的体力活动与HPV感染和宫颈癌发病风险之间的关系。[方法]收集2018年3月至2019年12月在中国科学院大学附属肿瘤医院接受宫颈HPV检查的11 730例女性资料,其1 185例利用大数据技术通过手机全球定位系统获得调查对象HPV检查半年前的运动数据,采用Logistic回归分析体力活动与HPV感染和宫颈癌发病的风险。[结果]参与调查对象共11 730例中,患有宫颈癌的女性任何高危型HPV或HPV16、18、31、33、45、52和58感染率明显较高。1 185例获运动数据的调查对象中,包括896例对照和289例宫颈癌。多因素Logistic回归分析结果显示,年龄、HPV16、18、31、52、58和平均每日体力活动时长与宫颈癌风险显著性相关。与每日体力活动时长≤60 min比较,每日体力活动时长61~100 min、101~140 min和>140 min者患宫颈癌的风险值分别为0.71(95%CI:0.47~1.08)、0.60(95%CI:0.38~0.95)和0.45(95%CI:0.28~0.73)。[结论]适度运动可能有助于降低宫颈癌的发病风险。
[Objective] To explore the relationship of physical activity monitored by global positioning system with the risk of cervical cancer. [Methods] Form March 2018 to December 2019, a total of11 730 women received cervical HPV examination in Cancer Hospital of University of Chinese Academy of Sciences. Among them, 1 185 cases whose physical activity was monitored for 6 months before HPV examination through the mobile phone global positioning system(GPS). Logistic regression was used to analyze the relationship between physical activity and the risk of cervical cancer. [Results]Women with cervical cancer had significantly higher prevalence of infection with high-risk HPV 16,18, 31, 33, 45, 52 and 58. Among 1 185 women whose physical activity was monitored, there were289 cases of cervical cancer. Multivariate Logistic regression analysis showed that age, HPV16, 18,31 52 58, and average daily physical activity time were significantly associated with the risk of cervical cancer. Compared with the daily physical activity ≤60 min, the OR values of physical activity of 61~100 min, 101~140 min and >140 min were 0.71(95%CI: 0.47~1.08), 0.60(95%CI: 0.38~0.95) and0.45(95%CI: 0.28~0.73), respectively. [Conclusion] Moderate exercise may help to reduce the risk of cervical cancer.
作者
邢洁
朱滔
羊文君
于爱军
XING Jie;ZHU Tao;YANG Wen-jun;YU Ai-jun(The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),In-stitute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou 310022,China)
出处
《肿瘤学杂志》
CAS
2022年第7期557-562,共6页
Journal of Chinese Oncology
基金
浙江省医药卫生科技项目(2018KY276,2019PY022)
浙江省医院可持续发展正大天晴研究项目(2019ZHAZDTQ207)。
关键词
体力活动
宫颈癌
人乳头状瘤病毒
运动数据
physical activity
cervical cancer
human papillomavirus
physical activity data
