摘要
目的探讨^(99)Tc^(m)-亚甲基二膦酸盐(MDP)SPECT/CT超级骨显像患者的影像学特征、临床表现、年龄及实验室检查结果的差异。方法收集2012年6月至2021年7月于宁夏医科大学总医院行^(99)Tc^(m)-MDP SPECT/CT显像的47 671例患者中呈超级骨显像的97例患者,其中男性54例、女性43例,年龄25~85(62.4±14.3)岁,回顾性分析97例患者的临床表现资料、影像学资料、年龄及实验室检查资料。根据病因不同,将患者分为骨转移瘤组(71例)与代谢性骨病组(26例,包括甲状旁腺瘤9例、肾性骨病6例、骨质疏松症11例)。根据原发肿瘤不同,将71例骨转移瘤组患者分为4个亚组[前列腺癌组(40例)、乳腺癌组(15例)、肺癌组(8例)、消化系统恶性肿瘤组(8例,包括胃癌4例、直肠癌2例、食管癌1例、原发性肝癌1例)]。统计分析骨转移瘤组与代谢性骨病组以及骨转移瘤组4个亚组之间^(99)Tc^(m)-MDP SPECT全身骨显像的特征、SPECT/CT融合显像的特征、临床表现、年龄和实验室检查[血钙、血磷、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)]结果的差异。计量资料的组间比较采用独立样本t检验、单因素方差分析、Wilcoxon秩和检验及Kruskal-WallisH检验;分类变量资料的组间比较采用χ^(2)检验。结果骨转移瘤(73.2%,71/97)是导致超级骨显像的最常见病因[在其原发肿瘤中,前列腺癌较常见(56.3%,40/71)],其次为代谢性骨病(26.8%,26/97)。骨转移瘤组以灶性散在分布型(Ⅱ型)为主(85.9%,61/71),代谢性骨病组主要呈均匀对称型(Ⅰ型)(61.5%,16/26),2组比较差异有统计学意义(χ^(2)=21.84,P<0.001)。骨转移瘤组以成骨型(74.6%,53/71)和混合型(19.7%、14/71)骨质破坏为主,而代谢性骨病组以溶骨型(73.1%,19/26)骨质破坏为主,差异均有统计学意义(χ^(2)=39.76、15.95,均P<0.001)。所有患者均以骨痛为初发症状,局部骨痛为主要临床表现(56.7%,55/97)。骨转移瘤组以腰痛最常见(60.0%,24/40),代
Objective To explore the differences in the imaging features,clinical manifestations,age,and laboratory examination results of patients who underwent ^(99)Tc^(m)-methylenediphosphonate(MDP)SPECT/CT super bone scan.Methods A total of 97 patients with super bone scan,including 54 males and 43 females,aged 25–85(62.4±14.3)years,were recruited from 47671 patients who underwent ^(99)Tc^(m)-MDP SPECT/CT imaging in the General Hospital of Ningxia Medical University from June 2012 to July 2021.The clinical manifestation,imaging,age,and laboratory examination data of the 97 patients were retrospectively analyzed.In accordance with different etiologies,the patients were divided into the bone metastases group(71 cases)and the metabolic bone disease group(26 cases,including parathyroid adenoma(9 cases),renal bone disease(6 cases),and osteoporosis(11 cases)).In accordance with the location of the primary tumor,71 patients with bone metastases were divided into four subgroups(prostate cancer group(40 cases);breast cancer group(15 cases);lung cancer group(8 cases);malignant digestive system tumors(8 cases),including gastric cancer(4 cases),rectal cancer(2 cases),esophageal cancer(1 case)and primary liver cancer(1 case)).The differences in ^(99)Tc^(m)-MDP SPECT whole-body bone scan and SPECT/CT fusion imaging features,clinical manifestations,age,and laboratory examination(serum calcium,serum phosphorus,alkaline phosphatase(ALP),and lactate dehydrogenase(LDH))results between the bone metastasis group and the metabolic bone disease group and among the four subgroups of the bone metastasis group were statistically analyzed.Independent samples t-test,one-way ANOVA,Wilcoxon rank sum test,and Kruskal-Wallis H test were used to compare measurement data,andχ^(2) test was applied to compare classified variable data.Results Bone metastases(73.2%,71/97)were the most common cause of super bone scan(among the primary tumors,prostate cancer was more common(56.3%,40/71),followed by metabolic bone disease(26.8%,26/97)).The bone metastasis g
作者
于亚萍
李永亮
冯蓓
姜杨宏岩
赵倩
Yu Yaping;Li Yongliang;Feng Bei;Jiang Yanghongyan;Zhao Qian(Department of Nuclear Medicine,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Graduate School of Ningxia Medical University,Yinchuan 750004,China)
出处
《国际放射医学核医学杂志》
2022年第6期325-333,共9页
International Journal of Radiation Medicine and Nuclear Medicine
