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阿尔茨海默病患者睡眠障碍及行为亚综合征分析 被引量:4

Sleep disturbance and hehavioral subsyndrome in patients with Alzheimer′s Disease
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摘要 目的探讨阿尔茨海默病(AD)患者睡眠障碍及精神行为(BPSD)亚综合征发生特点,并分析影响其发生原因。方法采用问卷调查方式收集2019年1月到2021年10月连云港市第一人民医院就诊的137例阿尔茨海默病患者人口学资料、病史、饮食习惯等,采用Excel 2007及SPSS 22.0软件进行统计分析睡眠障碍及BPSD亚综合征发生情况,并使用多因素logistic回归分析其发生的影响因素。结果137例患者存在82例睡眠障碍(59.85%)、118例BPSD亚综合征(86.13%),82例睡眠障碍患者主要存在睡眠质量低(87.80%,72/82)、睡眠时间不足(73.17%,60/82)及入睡困难(69.51%,57/82),118例BPSD亚综合征患者主要存在情感障碍(88.14%,104/118)、精神病性症状(76.27%,90/118)及高活动性(43.22%,51/118);多因素logistic回归分析显示,体力劳动、合并心脑血管疾病、饮食偏好、病情严重程度是影响患者出现睡眠障碍的高危因素(P<0.05),而性别、居住情况、睡眠障碍、照护人员是否专职、病情严重程度是影响患者出现BPSD亚综合征的高危因素(P<0.05)。结论阿尔茨海默病患者普遍存在不同类型的睡眠障碍和BPSD亚综合征,需关注高危患者并进行干预,以改善患者睡眠及精神状态。 Objective To investigate the characteristics of behavioral and psychological symptoms of dementia(BPSD)subsyndrome in patients with Alzheimer′s disease(AD)and analyze the causes.Methods The demographic data,medical history and dietary habits of 137 patients with Alzheimer′s disease who visited our hospital from January 2019 to October 2021 were collected by questionnaire.Excel 2007 and SPSS 22.0 software were used for statistical analysis of the occurrence of sleep disorders and BPSD subsyndrome.Multivariate logistic regression was used to analyze the influencing factors of its occurrence.Results There were 82 cases of sleep disorder(59.85%)and 118 cases of psycho-behavioral subsyndrome(86.13%)among those137 patients,of which 82 cases of sleep disorder mainly had low sleep quality(87.80%,72/82),insufficient sleep time(73.17%,60/82)and difficulty falling asleep(69.51%,57/82);of which 118 cases of BPSD subsyndrome mainly had affective disorder(88.14%,104/118),psychotic symptoms(76.27%,90/118)and high activity(43.22%,51/118).Multivariate logistic regression analysis showed that physical work,combined cerebral and cardiovascular diseases,dietary preference and severity of illness were the factors affecting sleep disorder(P<0.05),while gender,residence,sleep disorder,whether the caregivers were full-time and severity of illness were the factors affecting the occurrence of behavioral subsyndrome(P<0.05).Conclusion Different types of sleep disorders and BPSD subsyndromes are common in patients with Alzheimer′s disease.Attention should be paid to patients and intervention should be performed to improve their sleep and mental status.
作者 庞灵恩 周晓梅 孙永安 李娇娇 PANG Ling-en;ZHOU Xiao-mei;SUN Yong-an;LI Jiao-jiao(Department of Neurology,Lianyungang First People′s Hospital,Lianyungang,Jiangsu 222000,China)
出处 《公共卫生与预防医学》 2022年第5期154-157,共4页 Journal of Public Health and Preventive Medicine
关键词 阿尔茨海默病 睡眠障碍 行为亚综合征 患病率 Alzheimer′s disease Sleep disorder Behavioral subsyndrome Prevalence
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