摘要
目的 分析支气管肺炎患儿应用红霉素联合注射用哌拉西林钠他唑巴坦钠治疗的效果,探讨其应用价值。方法 选取齐齐哈尔市中医医院2019年11月—2021年9月收治的94例支气管肺炎患儿,应用双盲分组方式分为参照组与研究组,各47例。参照组对患儿施以注射用哌拉西林钠他唑巴坦钠药物治疗,研究组在参照组基础上联合使用红霉素药物治疗。对比两组患儿临床治疗效果、肺功能指标、炎症因子水平。结果 研究组患儿临床治疗总有效率(93.61%)与参照组对比,差异有统计学意义(χ^(2)=6.425,P=0.011);研究组患儿肺功能指标中每分钟静息通气量为(4.56±0.97)L、潮气量为(8.52±0.91)mL/kg,显著优于参照组,差异有统计学意义(t=3.670、7.755,P<0.001);研究组患儿炎症因子水平中肿瘤坏死因子-α为(3.87±0.65)ng/mL、白介素-6(14.01±1.56)ng/mL,显著优于参照组,差异有统计学意义(t=19.165、20.842,P<0.001)。结论 红霉素联合注射用哌拉西林钠他唑巴坦钠对支气管肺炎患儿施以治疗,有助于提高患儿治疗有效性,改善患儿肺功能指标与炎症因子水平,对患儿康复具有积极意义。
Objective To analyze the effect of erythromycin combined with piperacillin sodium and tazobactam sodium for injection in children with bronchopneumonia,and to explore its application value.Methods A total of 94 children with bronchopneumonia admitted to Qiqihar Traditional Chinese Medicine Hospital from November 2019 to September 2021 were divided into the control group and the study group by double-blind grouping method,with 47 cases in each group.The control group was treated with piperacillin sodium and tazobactam sodium for injection,and the study group was treated with erythromycin on the basis of the control group.The clinical treatment effect,lung function indexes and inflammatory factor levels were compared between the two groups.Results The total effective rate(93.61%) of clinical treatment of children in the study group was compared with that in the control group,and the difference was statistically significant(χ^(2)=6.425,P=0.011).Among the pulmonary function indexes of the children in the study group,the resting ventilation per minute was(4.56±0.97) L and the tidal volume was(8.52±0.91) mL/kg,which was significantly better than that of the reference group,the difference was statistically significant(t=3.670,7.755,P<0.001).The levels of tumor necrosis factor-α and interleukin-6 in the study group were(3.87±0.65) ng/mL and(14.01±1.56) ng/mL,respectively,which were significantly higher than those in the control group,the difference was statistically significant(t=19.165,20.842,P<0.001).Conclusion Erythromycin combined with piperacillin sodium and tazobactam sodium for injection in the treatment of children with bronchopneumonia will help to improve the effectiveness of the treatment in children.It can improve the level of lung function indexes and inflammatory factors in children,and has positive significance for the rehabilitation of children.
作者
孟莹
MENG Ying(Department of General Pediatrics,Qiqihar Hospital of Traditional Chinese Medicine South District,Qiqihar,Heilongjiang Province,161000 China)
出处
《系统医学》
2022年第14期145-148,共4页
Systems Medicine
关键词
红霉素
注射用哌拉西林钠他唑巴坦钠
小儿支气管肺炎
肺功能
炎症因子
Erythromycin
Piperacillin sodium and tazobactam sodium for injection
Bronchopneumonia in children
Lung function
Inflammatory factors
