摘要
目的 探讨丁苯酞联合尤瑞克林治疗急性缺血性脑卒中的临床效果。方法 选取徐州医科大学附属医院2019年10月—2021年3月收治的缺血性脑卒中患者80例,随机分为两组,研究组和对照组,各40例。对照组采用尤瑞克林治疗,研究组采用丁苯酞联合尤瑞克林,比较两组神经功能、认知状态,炎症反应及治疗效率。结果 研究组治疗2周后NIHSS评分(5.36±1.44)分低于对照组(7.15±1.55)分,MMSE评分(24.92±2.62)分高于对照组的(21.63±2.16)分,差异有统计学意义(t=5.351、6.128,P<0.05);研究组治疗2周后血清hs-CRP水平(6.52±2.45)mg/L、NLR(1.35±0.36)、PLR(109.34±18.19)均低于对照组,差异有统计学意义(t=5.605、7.193、5.082,P<0.05);研究组治疗2周后的总有效率为90.00%,高于对照组的72.50%,差异有统计学意义(χ^(2)=4.021,P<0.05)。结论 对急性缺血性脑卒中患者采用丁苯酞与尤瑞克林联合治疗,可改善患者神经功能缺损程度和认知状态,减轻炎症反应,提高治疗效率。
Objective To investigate the clinical effect of butylphthalide combined with Urinary Kallindinogenase in the treatment of acute ischemic stroke.Methods A total of 80 patients with ischemic stroke who were treated in Affiliated Hospital of Xuzhou Medical University from October 2019 to March 2021 were selected and randomly divided into two groups,the study group and the control group,with 40 cases in each.Butylphthalide combined with uricline was used to compare the neurological function,cognitive status,inflammatory response and treatment efficiency between the two groups.Results After 2 weeks of treatment,the NIHSS score(5.36±1.44) points in the study group was lower than that in the control group(7.15±1.55) points,and the MMSE score(24.92±2.62) points was higher than that in the control group(21.63±2.16) points,the difference was statistically significant(t=5.351,6.128,P<0.05);after 2 weeks of treatment,the serum hs-CRP level(6.52±2.45) mg/L,NLR(1.35±0.36) and PLR(109.34±18.19) in the study group were lower than those in the control group,and the difference was statistically significant(t=5.605,7.193,5.082,P<0.05);after 2 weeks of treatment,the total effective rate of the study group was 90.00%,which was higher than that of the control group 72.50%,and the difference was statistically significant(χ^(2)=4.021,P<0.05).Conclusion The combined treatment of butylphthalide and Urinary Kallindinogenase in patients with acute ischemic stroke can improve the degree of neurological deficit and cognitive state,reduce inflammatory response,and improve treatment efficiency.
作者
许艳
XU Yan(Department of Neurology,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu Province,221000 China)
出处
《系统医学》
2022年第14期120-123,157,共5页
Systems Medicine
关键词
丁苯酞
尤瑞克林
急性缺血性脑卒中
神经功能
认知状态
炎症反应
Butylphthalide
Urinary Kallindinogenase
Acute ischemic stroke
Neurological function
Cognitive state
Inflammatory response
