摘要
目的 研究血糖与糖化血红蛋白(glycosylated hemoglobin,HbA1c)检验诊断糖尿病的特异度与敏感度。方法 选取2021年2月—2022年2月福州市第二医院收治的60例糖尿病患者作为研究组,将同期收治的60名健康体检者作为对照组。对两组患者进行血糖、HbA1c水平检测,绘制受试者工作特征(receiver operating characteristic,ROC)曲线,分析其诊断价值。结果 (1)研究组HbA1c、PBG、FBG水平均高于对照组,差异有统计学意义(P<0.05);(2) Pearson相关性分析结果显示,研究组患者的HbA1c与FBG、PBG均呈正相关(r=0.792、0.528,P<0.05);PBG>11.1 mmol/L对糖尿病的诊断特异度为55.0%、敏感度为81.7%;FBG>7.0 mmol/L对糖尿病的诊断特异度为98.3%、敏感度为98.3%;HbA1c>6.5%对糖尿病的诊断敏感度为100.0%、特异度为91.7%。结论 HbA1c、FBG、PBG是诊断糖尿病的主要生化指标,诊断特异度高,对糖尿病患者的病情评估有重要作用。
Objective To study the specificity and sensitivity of blood glucose and glycated hemoglobin(HbA1c)test in the diagnosis of diabetes.Methods A total of 60 diabetic patients admitted to Fuzhou Second Hospital from February 2021 to February 2022 were selected as the study group.The 60 healthy subjects who were treated in the same period were used as the control group.Blood glucose and HbA1c levels were detected in the two groups of patients,and receiver operating characteristic(ROC)curves were drawn to analyze their diagnostic value.Results 1.The levels of HbA1c,PBG and FBG in the study group were higher than those in the control group,the difference was statistically significant(P<0.05).2.The results of Pearson correlation analysis showed that the HbA1c of the study group was positively correlated with FBG and PBG(r=0.792,0.528,P<0.05).The specificity and sensitivity of PBG>11.1 mmol/L for the diagnosis of diabetes were 55.0%and 81.7%.The specificity and sensitivity of FBG>7.0 mmol/L for the diagnosis of diabetes were 98.3%and 98.3%.The sensitivity and specificity of HbA1c>6.5%for the diagnosis of diabetes were 100.0%and 91.7%.Conclusion HbA1c,FBG and PBG are the main biochemical indicators for the diagnosis of diabetes,with high diagnostic specificity,which play an important role in the evaluation of the condition of diabetic patients.
作者
张蕊
ZHANG Rui(Department of Laboratory Medicine,Fuzhou Second Hospital,Fuzhou,Fujian Province,350000 China)
出处
《糖尿病新世界》
2022年第14期64-66,74,共4页
Diabetes New World Magazine
