摘要
缺血性卒中又称脑梗死,是脑卒中最常见的类型。缺血性卒中危害极大,其患病率、发病率、致残率和死亡率均位居前列,给社会和家庭造成巨大负担。因此,寻找新的、有效的防治方法极为迫切。缺血性卒中的病理机制十分复杂且相互叠加,其中炎症反应是缺血性卒中级联损伤过程中的关键病理环节。NOD样受体蛋白3(NLRP3)是一种细胞内传感器,活化的NLRP3炎症小体介导的炎症级联反应通过释放炎症因子等能加剧缺血性卒中损伤。中医药领域以NLRP3炎症小体为切入点,开展了大量中医药干预NLRP3炎症小体的组装和激活的实验研究,证明了以补虚、清热解毒、祛痰、活血化瘀等为主要功效的中药单体或组方制剂能干预NLRP3炎症小体的组装和激活,降低炎症反应,从而缓解缺血性卒中。本研究从NLRP3炎症小体的组装和激活,NLRP3炎症小体在缺血性卒中的作用和中医药通过调控NLRP3炎症小体防治缺血性卒中方面进行综述,旨在为缺血性卒中的病理机制提供新的切入点,为开发缺血性卒中新的治疗手段提供方向。
Ischemic stroke,also known as cerebral infarction,is the most common type of stroke.Ischemic stroke is extremely harmful with high rates of morbidity,incidence,disability,and mortality,bringing a huge burden on society and families.As a result,finding new and effective prevention and treatment methods is critical.The pathological mechanism of ischemic stroke is very complex and superimposed,with inflammatory response serving as a critical pathological link in the ischemic stroke cascade injury process.NOD-like receptor 3(NLRP3) is an intracellular sensor,and the inflammatory cascade mediated by the activated NLRP3inflammasome can exacerbate ischemic stroke injury through the release of inflammatory factors.Taking the NLRP3 inflammasome as the entry point,a large number of experimental studies on the intervention of traditional Chinese medicine(TCM)in the assembly and activation of NLRP3 inflammasome have been carried out,which proved that Chinese medicinal monomers or prescriptions with the main functions of tonifying deficiency,clearing heat and removing toxin,eliminating phlegm,promoting circulation and resolving stasis can interfere with the assembly and activation of NLRP3 inflammasome,reduce the inflammatory response,and relieve ischemic stroke.This study reviewed the assembly and activation of NLRP3 inflammasome,the mechanism of NLRP3 inflammasome in ischemic stroke,and the prevention and treatment of ischemic stroke by TCM through regulation of the NLRP3 inflammasome,which provides a new entry point for the pathological mechanism of ischemic stroke and a direction for the development of new treatments for ischemic stroke.
作者
刘迅
李钰佳
罗政
周月
邓奕辉
LIU Xun;LI Yujia;LUO Zheng;ZHOU Yue;DENG Yihui(Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第18期225-236,共12页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81874416)
湖南省研究生科研创新项目(QL20210175)
湖南中医药大学中西医结合一流学科开放基金项目(2020ZXYJH32)。
关键词
NOD样受体3
炎症小体
缺血性卒中
中医药
NOD-like receptor 3(NLRP3)
inflammasome
ischemic stroke
traditional Chinese medicine
