摘要
目的探讨益气消瘿法对气虚痰凝型非毒性结节性甲状腺肿(NTNG)预后的影响。方法选取2019年1月至2020年12月间上海中医药大学附属普陀医院收治的90例NTNG患者,随机分为观察组和对照组,每组45例。对照组患者口服左甲状腺素钠片,观察组患者在对照组基础上口服益气消瘿汤,比较两组患者治疗前后的主要症状积分、最大结节直径、甲状腺结节数目、临床疗效和安全性。结果观察组患者临床总有效率为88.9%,高于对照组的71.1%,两组比较,差异有统计学意义(P<0.05)。治疗后,观察组患者颈部肿大、颈部胀闷、胸肋胀闷及神疲乏力积分均降低,对照组颈部肿大积分降低,且观察组均低于对照组,差异均有统计学意义(均P<0.05)。治疗后,两组患者最大结节直径和甲状腺结节数目均降低,且观察组均低于对照组,差异均有统计学意义(均P<0.05)。治疗前后,两组患者甲状腺功能、甲状腺自身抗体、肝功能、肾功能均未发生异常,治疗中均未出现明显不良反应。结论益气消瘿法联合左甲状腺素钠片治疗气虚痰凝型NTNG,能有效缓解患者局部症状,缩小最大结节直径,减少结节数目,安全性高,有助于改善疾病预后。
Objective To observe the effect of Yiqi Xiaoying therapy on prognosis of patients with nontoxic nodular goiter(NTNG) due to qi deficiency sputum coagulation. Methods Ninety NTNG patients were selected at Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between January 2019 and December 2020. They were randomly divided into an observation group and a control group with 45 patients in each group. The observation group was given Yiqi Xiaoying decoction besides and the control group was given levothyroxine sodium tablets alone. Changes in main symptom scores, maximum nodule diameter and number of thyroid nodules were compared between the two groups before and after treatment. Results The overall efficacy rate was 88.9% in the observation group, which was higher than 71.1% of the control group(P<0.05). After treatment, the scores of cervical swelling, neck distension, chest rib distension and mental fatigue were lower in the observation group than those in the control group(all P<0.05). Moreover, the maximum nodule diameter and the number of thyroid nodules were lower in the observation group than those in the control group(all P<0.05). Conclusion Yiqi Xiaoying therapy combined with levothyroxine sodium tablets in the treatment of nontoxic nodular goiter due to qi deficiency sputum coagulation can effectively relieve the local symptoms, reduce the maximum diameter of nodules and the number of nodules, with significant curative effect and high safety, which is helpful to improve the prognosis of the disease.
作者
刘鑫晔
沈红权
张志丹
丁茜
LIU Xin-ye;SHEN Hong-quan;ZHANG Zhi-dan;DING Qian(Department of Traditional Chinese Medicine,Putuo Hospital Affliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)
出处
《中国肿瘤临床与康复》
2022年第7期811-814,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
上海市普陀区中医临床重点专科建设(ptzyzk2107)。
